Table 2.

The most common drugs implicated in drug-induced liver injury cases (drugs with n ≥ 5) in both the discovery sample and in the individuals available in the Drug-Induced Liver Injury Network replication cohort

	N (%)
Drugs	Discovery sample	Replication sample
Amoxicillin/clavulanate	208 (26.6)	42 (13.7)
Flucloxacillin	75 (9.6)	0 (0.0)
Diclofenac	30 (3.8)	4 (1.3)
Nitrofurantoin	24 (3.1)	15 (4.9)
Isoniazid	17 (2.2)	7 (2.3)
Sulfamethoxazole/trimethoprim	14 (1.8)	14 (4.6)
Valproic acid	13 (1.7)	2 (0.6)
Nimesulide	12 (1.5)	0 (0.0)
Minocycline	10 (1.3)	17 (5.5)
Celecoxib	8 (1.0)	1 (0.3)
Flucloxacillin and amoxicillin/  clavulanate	8 (1.0)	0 (0.0)
Ciprofloxacin	7 (0.9)	9 (2.9)
Phenytoin	7 (0.9)	1 (0.3)
Azathioprine	6 (0.8)	5 (1.6)
Duloxetine	6 (0.8)	0 (0.0)
Telithromycin	6 (0.8)	0 (0.0)
Atorvastatin	5 (0.6)	3 (1.0)
Simvastatin	5 (0.6)	4 (1.3)
All other drugs and combinations	322 (41.1)	183 (59.6)