Table 3.
The top-associated variants in all drug-induced liver injury casesa for all single-nucleotide polymorphisms and selected subsets of single-nucleotide polymorphisms associated with absorption, distribution, metabolism, and excretion and autoimmune genes
| SNP Sets | SNP | P-value | Chromosome:coordinate | Function | Nearest gene |
|---|---|---|---|---|---|
| Genome-wide | rs35709459 | 1.99E – 07 | X:91516677 | Intronic | PCDH11X |
| rs35925943 | 1.38E – 06 | X:91516339 | Intronic | PCDH11X | |
| rs11767067 | 1.64E – 06 | 7:93022840 | Intergenic | CALCR | |
| rs1187997 | 2.18E – 06 | 1:58455538 | Intronic | DAB1 | |
| rs656437 | 4.24E – 06 | 11:95770378 | Intronic | MAML2 | |
| ADME subset | rs3740065 | 0.0001 | 10:101605693 | Intronic | ABCC2 |
| rs2756113 | 0.0008 | 10:101569371 | Intronic | ABCC2 | |
| rs2804397 | 0.0011 | 10:101559415 | Intronic | ABCC2 | |
| rs8187710 | 0.0013 | 10:101611294 | Missense (C1515Y) | ABCC2 | |
| rs11816708 | 0.0013 | 10:101615015 | Downstream | ABCC2 | |
| Autoimmune subset | rs2476601 | 2.26E – 05 | 1:114377568 | Missense (R620W) | PTPN22 |
| rs6679677 | 4.18E – 05 | 1:114303808 | Upstream | RSBN1 | |
| rs7202877 | 0.0002 | 16:75247245 | Intergenic | CTRB1 | |
| rs1464510 | 0.003 | 3:188112554 | Intronic | LPP | |
| rs12928822 | 0.0033 | 16:11403893 | Upstream | MIR548H2 |
ADME, absorption, distribution, metabolism, and excretion; SNP, single-nucleotide polymorphism.
a
Analysis conditioned on rs2395029, rs2523822, and rs3135388, known to be highly associated with drug-induced liver injury due to flucloxacillin or amoxicillin/clavulanate.