Table 1.
Inhibition of translation in A. suum extract by N2-modified cap analogues
| |||||
|---|---|---|---|---|---|
| R = | IC50 | R = | IC50 | ||
| 32 |
|
2.9 μM | 39 |
|
>50 μM |
| 33 |
|
>50 μM | 40 |
|
3.9 μM |
| 34 |
|
>50 μM | 41 |
|
>50 μM |
| 42 |
|
4.5 μM | |||
| 35 |
|
0.9 μM | 43 |
|
>50 μM |
| 36 |
|
3.8 μM | 44 |
|
13.9 μM |
| 37 |
|
12.6 μM | 45 |
|
5.7 μM |
| 38 |
|
4.3 μM | m7GTP | 6.1 μM | |
| m7GMP | >50μM | ||||
IC50 values were extracted directly from the plotted of % translation activity values against compound concentration. IC50 values > 50 μM - no measurable effect.