Table 1.
Inhibition of translation in A. suum extract by N2-modified cap analogues
![]() | |||||
---|---|---|---|---|---|
R = | IC50 | R = | IC50 | ||
32 |
![]() |
2.9 μM | 39 |
![]() |
>50 μM |
33 |
![]() |
>50 μM | 40 |
![]() |
3.9 μM |
34 |
![]() |
>50 μM | 41 |
![]() |
>50 μM |
42 |
![]() |
4.5 μM | |||
35 |
![]() |
0.9 μM | 43 |
![]() |
>50 μM |
36 |
![]() |
3.8 μM | 44 |
![]() |
13.9 μM |
37 |
![]() |
12.6 μM | 45 |
![]() |
5.7 μM |
38 |
![]() |
4.3 μM | m7GTP | 6.1 μM | |
m7GMP | >50μM |
IC50 values were extracted directly from the plotted of % translation activity values against compound concentration. IC50 values > 50 μM - no measurable effect.