Table 3.
Targets of miRNAs that promote differentiation of neural stem cells
| MicroRNA | Targets | Source |
|---|---|---|
| Let-7 | TLX | Sun et al., 2011; |
| Zhao et al., 2010 | ||
| Mlin41/Trim71 | Maller Schulman et al., 2008 | |
| miR-9 | Hairy1 | Bonev et al., 2011 |
| Stathmin | Delaloy and Gao, 2010 | |
| Notch-1 | Jing et al., 2011 | |
| STAT3 | Mukhopadhyay et al., 2011 | |
| miR-17-3p | Olig2/lrx3 | Chen et al., 2011 |
| miR-17~92, -106a~363, -106b~25 (paralogous clusters) | Various components of MAPK cascade | Mukhopadhyay et al., 2011 |
| miR-19a and -19b | Lrp2 (Megalin), RhoB, IGF, Wnt, and MAPK pathways | Mukhopadhyay et al., 2011 |
| miR-23 | Sox9 | Farrell et al., 2011 |
| miR-34a | SIRT1, p53 | Aranha et al., 2011 |
| miR-124 | Sox9 | Farrell et al., 2011 |
| Integrins (e.g. Itgβ1, Itga7, Itgα3, Itgα11), STAT3 | Mukhopadhyay et al., 2011 | |
| SNAI2 | Xia et al., 2012 | |
| miR-125 | Mlin41/Trim71 | Maller Schulman et al., 2008 |
| miR-126 | HOXA9, HOXA3? | Wei et al., 2010 |
| miR-134 | Chrdl-1, Dcx | Gaughwin et al., 2011 |
| miR-135 | ? | Arnold et al., 2011 |
| miR-137 | TLX | Sun et al., 2011; |
| Zhao et al., 2010 | ||
| miR-181 | LIN28 | X. Li et al., 2012 |
| miR-183 | mSEL-1L | Cardano et al., 2011 |
| miR-196 | Hoxb8 | Asli et al., 2010 |
| miR-371-3 | BMP inhibitors (e.g. BAMBI, CHRD, CRIM1)? | Kim et al., 2011 |
Until they receive signals to undergo differentiation, NSCs will remain in a proliferative state. miRNAs that promote differentiation will often target transcription factors such as TLX and Sox9. NSCs exiting the proliferative state will become neuronal and/or glial precursors and may express different miRNA profiles before arriving at a particular cell fate. Note: LIN28 is a RNA-binding protein, not a miRNA.