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Heterotrimeric PP2A holoenzymes consist of a catalytic, a scaffold, and a regulatory subunit. The B regulatory subunit is responsible for substrate specificity and/or subcellular localization and can be any member from 4 unrelated families (B, B’, B’’, and B’’’). Scaffold and catalytic subunits are encoded each by 2 separate genes. Gene symbols and common protein names are listed.
