Table 1.

Alterations in PP2A Subunits in Cancer

Mutation	Cancer Type	Ref.	Effect on Binding	Ref.
PP2A/Aα
E64D	Lung	51	B’ binding deficient	54
E64G	Breast	51	B’ binding deficient	54
R418W	Melanoma	51	No B or C binding	54
D171-589	Breast	51	No B or C binding	54
P179L	Endometrial	95	Unknown
R182W	Endometrial	95	Unknown
S256Y	Endometrial	95	Unknown
R183Q	Endometrial	95	Unknown
R249H	Endometrial	95	Unknown
R182W	Endometrial	95	Unknown
E216K	Endometrial	96	Unknown
R258Y	Endometrial	96	Unknown
R258H	Endometrial	96	Unknown
R258C	Ovarian	95	Unknown
W257C	Endometrial, ovarian	95, 96	Unknown
P179R	Endometrial, ovarian	95	Unknown
R183W	Endometrial, ovarian	95	Unknown
S256F	Endometrial, ovarian	95	Unknown
W257G	Endometrial, ovarian	95	Unknown
PP2A/Aβ
D504G	Lung	50	Increased B’’ and C binding	53
G8R	Lung	50	Normal B’’ and C binding	53
G90D	Lung	50	Normal B’’ and C binding	53
	Breast	97	Reduced B’ binding	97
K343E	Lung	50	Normal B’’ and C binding	53
D344-388	Lung	50	Reduced B’’ binding	53
P65S	Lung	50	Reduced B’’ binding	53
L101P	Colon	50	Reduced B’’ binding	53
V545A	Colon	50	Reduced B’’ and C binding	53
V448A	Colon	50	Reduced B’’ and C binding	53
L101P/V448A	Colon	50	Reduced B’’ and C binding	53
D230-518	Lung	50	Unknown
G15A	Colorectal	98	Unknown
S365P	Colorectal	98	Unknown
V498E	Colorectal	98	Unknown
L499I	Colorectal	98	Unknown
V500G	Colorectal	98	Unknown
Deletions	Liver	99	Unknown
PP2A/B55α
Deletions	Breast	64
Deletions	Prostate	58
Deletions	Ovarian	65
PP2A/B55β
Hypermethylation	Colorectal	66
Hypermethylation	Breast	67