Table 3.
Summary effects analyses adjusted for team, ethnic origin, age at study, and sex
| dbSNP number | Overall |
White, non-Hispanic only |
|||||||
|---|---|---|---|---|---|---|---|---|---|
| SNP | N (alleles) | RE OR (95% CI) | FE OR (95% CI) | pHet (I2%) | N (alleles) | RE OR (95% CI) | FE OR (95% CI) | pHet (I2%) | |
| 1 | rs7702187 | 24 (23554) | 1·01 (0·93-1·10) | 1·00 (0·93-1·07) | 0·30 (12) | 13 (20850) | 1·00 (0·92-1·08) | 1·00 (0·92-1·08) | 0·51 (0) |
| 2 | rs10200894 | 24 (23156) | 1·05 (0·96-1·15) | 1·05 (0·96-1·15) | 0·71 (0) | 13 (20440) | 1·08 (0·98-1·20) | 1·08 (0·98-1·20) | 0·62 (0) |
| 3 | rs2313982 | 22 (23366) | 0·94 (0·83-1·07) | 0·94 (0·85-1·04) | 0·29 (13) | 13 (20770) | 0·96 (0·85-1·09) | 0·96 (0·86-1·07) | 0·34 (11) |
| 4 | rs17329669 | 24 (23338) | 0·90 (0·81-1·01) | 0·94 (0·87-1·02) | 0·14 (24) | 13 (20622) | 0·89 (0·78-1·01) | 0·94 (0·87-1·02) | 0·02* (51) |
| 5 | rs7723605 | 24 (23366) | 1·08 (0·97-1·19) | 1·07 (0·99-1·16) | 0·12 (26) | 13 (20668) | 1·09 (0·99-1·19) | 1·08 (1·00-1·18) | 0·40 (5) |
| 6 | ss46548856 | 23 (23404) | 1·03 (0·95-1·13) | 1·03 (0·95-1·13) | 0·45 (1) | 13 (20808) | 1·06 (0·96-1·16) | 1·06 (0·96-1·16) | 0·63 (0) |
| 7 | rs16851009 | 24 (22654) | 1·05 (0·93-1·19) | 1·06 (0·97-1·16) | 0·11 (27) | 13 (19944) | 1·00 (0·89-1·13) | 1·01 (0·91-1·11) | 0·22 (22) |
| 8 | rs2245218 | 23 (23364) | 1·04 (0·97-1·12) | 1·04 (0·97-1·12) | 0·74 (0) | 13 (20698) | 1·05 (0·97-1·13) | 1·05 (0·97-1·13) | 0·70 (0) |
| 9 | rs7878232 | 24 (15046) | 0·93 (0·86-1·01) | 0·93 (0·86-1·01) | 0·75 (0) | 13 (12952) | 0·92 (0·85-1·00) | 0·92 (0·85-1·00) | 0·73 (0) |
| 10 | rs1509269 | 22 (23076) | 0·94 (0·82-1·07) | 0·95 (0·86-1·04) | 0·13 (26) | 13 (20488) | 0·96 (0·84-1·10) | 0·96 (0·88-1·06) | 0·11 (34) |
| 11 | rs11737074 | 24 (23432) | 0·95 (0·87-1·04) | 0·97 (0·90-1·04) | 0·25 (15) | 13 (20714) | 0·98 (0·92-1·06) | 0·98 (0·92-1·06) | 0·67 (0) |
| 12 | rs682705 | 24 (20362) | 0·99 (0·92-1·06) | 0·99 (0·93-1·05) | 0·41 (4) | 13 (17652) | 0·99 (0·92-1·06) | 0·99 (0·92-1·06) | 0·94 (0) |
| 13 | rs7520966 | 24 (23324) | 0·99 (0·92-1·06) | 0·99 (0·93-1·05) | 0·33 (10) | 13 (20608) | 0·98 (0·92-1·04) | 0·98 (0·92-1·04) | 0·92 (0) |
N=number of teams and ethnic subgroups contributing to the analysis. FE=fixed effects. RE=random effects. The reference allele was the major frequency allele for all SNPs, except for SNP3 (rs2313982), SNP8 (rs2245218), and SNP10 (rs1509269).
*
Nominal statistical significance without correction for multiple comparisons (p<0·05 for summary ORs and pHet<0·10 for heterogeneity).