Table 5.
Density of CD1a+ Dendritic Cells, CD4+ T Cells, and CD8+ T Cells in the Foreskin Epidermis and Dermis Among 79 Males
| HPV Exposure Category,a by Cell Type | Density, Cells/mm2, Median (IQR) | P |
|---|---|---|
| Dendritic cells | ||
| Epidermal CD1a+ cells | ||
| Persistently negative | 32.1 (3.1–96.2) | Reference |
| Acquired | 54.2 (16.2–72.5) | .32 |
| Cleared | 72.0 (29.4–138.3) | .047 |
| Cleared and acquired | 56.3 (13.7–63.8) | .37 |
| Dermal CD1a+ cells | ||
| Persistently negative | 2.6 (0.0–9.7) | Reference |
| Acquired | 3.8 (1.4–7.4) | 1.00 |
| Cleared | 6.8 (1.6–12.0) | .28 |
| Cleared and acquired | 6.4 (1.8–10.0) | .34 |
| CD4+ T cells | ||
| Epidermal CD4+ T cells | ||
| Persistently negative | 3.2 (0.8–7.0) | Reference |
| Acquired | 8.6 (1.9–18.6) | .15 |
| Cleared | 4.3 (1.2–22.9) | .34 |
| Cleared and acquired | 3.9 (0.9–6.1) | .99 |
| Dermal CD4+ T cells | ||
| Persistently negative | 22.3 (10.2–53.3) | Reference |
| Acquired | 47.0 (12.1–71.7) | .70 |
| Cleared | 22.48 (12.0–88.0) | .76 |
| Cleared and acquired | 23.0 (4.1–63.3) | .47 |
| CD8+ T cells | ||
| Epidermal CD8+ T cells | ||
| Persistently negative | 4.5 (0.8–17.6) | Reference |
| Acquired | 11.0 (3.2–33.6) | .17 |
| Cleared | 6.8 (1.5–54.2) | .40 |
| Cleared and acquired | 6.8 (1.7–21.7) | .76 |
| Dermal CD8+ T cells | ||
| Persistently negative | 17.8 (7.5–49.2) | Reference |
| Acquired | 7.9 (5.4–30.7) | .43 |
| Cleared | 35.4 (2.1–55.9) | .74 |
| Cleared and acquired | 14.9 (4.7–34.2) | .45 |
Males were randomly selected from the parent trial evaluating male circumcision for human immunodeficiency virus infection and sexually transmitted infection prevention, as described in Methods. A total of 23 males were persistently negative for human papillomavirus (HPV), 16 acquired HPV, 19 cleared HPV, and 21 cleared and acquired HPV.
Abbreviation: IQR, interquartile range.
aHPV classified based on either HR-HPV or LR-HPV.