Table 1.
Baseline patient demographic, clinical, laboratory, and inflammatory measurements in a cohort of 347 patients receiving MHD
| Variable | Alive (n=205) | Dead (n=142) | P Value |
|---|---|---|---|
| Demographic | |||
| Age (yr) | 51 (40–60) | 64 (55–71) | <0.01 |
| Women (%) | 54 | 40 | 0.01 |
| African American (%) | 25 | 30 | 0.33 |
| Hispanic (%) | 57 | 49 | 0.15 |
| Clinical | |||
| History of CVD (%) | 43 | 51 | 0.18 |
| Diabetes mellitus (%) | 44 | 67 | <0.01 |
| Charlson comorbidity index | 2 (0–3) | 3 (1–4) | <0.01 |
| Near-infrared body fat (%) | 25 (17–34) | 29 (21–36) | 0.02 |
| BMI (kg/m2) | 25.4 (22.0–29.1) | 25.1 (22.1–30.1) | 0.97 |
| Dialysis vintage (mo) | 27 (13–52) | 26 (13–53) | 0.98 |
| Dialysis dose in Kt/V (single pool) | 1.5 (1.4–1.7) | 1.5 (1.4–1.7) | 0.26 |
| NPCR (g/kg per day) | 1.1 (0.93–1.2) | 1.0 (0.85–1.2) | 0.03 |
| Administered erythropoietin (U/wk) | 11,150 (6030–16,970) | 14,630 (7846–21,810) | <0.01 |
| Predialysis systolic BP (mmHg) | 147 (133–166) | 152 (134–168) | 0.54 |
| Laboratory | |||
| BUN (mg/dl) | 66 (54–77) | 64 (51–78) | 0.31 |
| Creatinine (mg/dl) | 11 (9.3–14) | 9.4 (7.5–11.2) | <0.01 |
| Total cholesterol (mg/dl) | 144 (123–175) | 135 (108–172) | 0.08 |
| Albumin (g/dl) | 3.9 (3.7–4.2) | 3.8 (3.5–3.9) | <0.01 |
| Calcium (mg/dl) | 9.3 (8.9–9.8) | 9.2 (8.8–9.6) | 0.23 |
| Phosphorous (mg/dl) | 5.8 (4.8–6.9) | 5.7 (4.6–6.7) | 0.70 |
| Intact parathyroid hormone (pg/ml) | 215 (133–416) | 256 (144–405) | 0.63 |
| Blood hemoglobin (g/dl) | 12 (11–12.6) | 12 (11–12.6) | 0.68 |
| Bicarbonate (HCO3−) (mEq/L) | 22.0 (20–24) | 22 (20–24) | 0.59 |
| Inflammatory markers | |||
| PBHcit (mmol/mol Lys) | 0.179 (0.136–0.220) | 0.200 (0.252–0.142) | 0.02 |
| Total homocysteine (µmol/L) | 22 (18–27) | 22 (18–28) | 0.74 |
| MPO (pmol/L) | 735 (422–1351) | 837 (428–1401) | 0.37 |
| CRP (mg/L) | 3.5 (1.6–7.3) | 5.2 (2.7–8.9) | <0.01 |
| IL-6 (ng/L) | 6.5 (4.0–13) | 12.4 (7.1–24) | <0.01 |
| TNF-α (ng/L) | 7.1 (5.0–9.1) | 6.6 (4.7–9.2) | 0.53 |
| Lactate dehydrogenase (U/L) | 155 (137–182) | 164 (138–189) | 0.11 |
| WBC count (×1000) | 6.9 (5.6–8.2) | 7.0 (5.9–8.7) | 0.19 |
Unless otherwise noted, data are expressed as medians with interquartile ranges. BMI, body mass index; NPCR, normalized protein catabolic rate; WBC, white blood cell.