Table 2.
Lupus nephritis morphologic features according by APOL1 genotype
| APOL1 Risk Allele Status | |||||||
|---|---|---|---|---|---|---|---|
| Number (%) Global Glomerulosclerosis | Number (%) Total FSGS NOS | Number (%) Cases with Crescents | Number (%) Non-Necrotizing Crescents | Number (%) TMA | Number (%) MCTD | Mean Activity/Chronicity Score | |
| Zero risk alleles (n=188) | 105 (56%) | 84 (45%) | 67 (36%) | 35 (19%) | 13 (7%) | 20 (11%) | 4.3/2.9 |
| One risk allele (n=264) | 156 (59%) | 114 (43%) | 84 (32%) | 53 (20%) | 11 (4%) | 33 (13%) | 3.6/3.4 |
| Two risk alleles (n=94) | 53 (56%) | 52 (55%) | 42 (45%) | 30 (32%) | 8 (9%) | 24 (26%) | 4.2/3.9 |
NOS, not otherwise specified; TMA, thrombotic microangiopathy; MCTD, microcystic tubular dilatation.