Table 1.

Risk Estimates for Newly Identified SNPs Associated With Colorectal Cancer at a P Value Less Than 5 × 10⁻⁷

SNP	Chromosome (gene)a	Risk allele	Stageb	RAF (range)c	OR (95% CI)	P value	P heterogeneity
SNP with P < 5 × 10−8
rs11903757	2q32.3 (NABP1)	C	GWAS	0.16 (0.11–0.23)	1.15 (1.09–1.22)	1.38E-06
			Asian	0.05 (0.04–0.08)	1.16 (0.95–1.41)	1.34E-01
			Adenoma	0.15	1.23 (1.03–1.47)	2.30E-02
			Overall		1.16 (1.10–1.22)	3.71E-08	.27
SNPs with P < 5 × 10−7and P > 5 × 10−8
rs10911251	1q25.3 (LAMC1)	A	GWAS	0.57 (0.49–0.63)	1.10 (1.06–1.14)	1.34E-06
			Asian	0.54 (0.50–0.55)	1.09 (1.01–1.17)	3.20E-02
			Adenoma	0.58	1.06 (0.93–1.21)	3.66E-01
			Overall		1.09 (1.06–1.13)	9.45E-08	.69
rs3217810	12p13.32 (CCND2)	T	GWAS	0.16 (0.18–0.10)	1.19 (1.11–1.28)	3.40E-07
			Asian	NA	NA	NA
			Adenoma	0.15	1.31 (1.00–1.71)	5.07E-02
			Overall		1.20 (1.12–1.28)	5.86E-08	.91
rs3217901	12p13.32 (CCND2)	G	GWAS	0.41 (0.43–0.39)	1.10 (1.06–1.15)	1.71E-06
			Asian	0.56 (0.54–0.58)	1.08 (0.98–1.18)	1.04E-01
			Adenoma	0.42	1.08 (0.91–1.27)	3.72E-01
			Overall		1.10 (1.06–1.14)	3.31E-07	.51
rs59336	12q24.21 (TBX3)	T	GWAS	0.48 (0.51–0.42)	1.10 (1.06–1.14)	7.64E-07
			Asian	0.60 (0.56–0.62)	1.05 (0.94–1.18)	3.61E-01
			Adenoma	0.48	1.13 (0.90–1.40)	2.89E-01
			Overall		1.09 (1.06–1.13)	3.67E-07	.39

CI, confidence interval; RAF, risk allele frequency.

NOTE. Bolded entries signify combined results.

^aChromosome position and build from Genome Browser based on build 37.

^bGWAS (n = 12,696 cases and 15,113 controls); Asian (2098 cases and 5749 controls); adenoma (958 cases and 909 controls); overall (15,752 cases and 21,771 controls except for rs3217810, which has 13,654 cases and 16,022 controls).

^cMean and (range) computed from respective studies.