TABLE 4.
Parameter values used for the computational simulations
| Name | Definition | Value | Reference/Source |
|---|---|---|---|
| aTcell | Area of an activated T cell | 452 μm2 | Ref. 1 |
| aDC | Area of a dendritic cell | 1256 μm | Ref. 1 |
| asyn | Area of synapse (c-SMAC) | 12.6 μm2 | Ref. 1 |
| γDC | Rate constant for molecules on DC diffusing into synapse | 2.7 × 10−4 s−1 | Ref. 1 |
| κDC | Rate constant for molecules on DC diffusing out from synapse | 2.7 × 10−2 s−1 | Ref. 1 |
| γT | Rate constant for molecules on T cells diffusing into synapse | 1.0 × 10−3 s−1 | Ref. 1 |
| κT | Rate constant for molecules on T cells diffusing out from synapse | 3.6 × 10−2 s−1 | Ref. 1 |
| m | Fraction of mobile cell surface molecules | 0.6a | Ref. 3 |
| α1 | Association of PD-1 and PD-L1 | 0.10 μm2 s−1 | This work |
| α2 | Association of PD-1 and PD-L2 | 0.14 μm2 s−1 | This work |
| α3 | Association of B7-1 and PD-L1 | 0.17 μm2 s−1 | This work |
| α4 | Association of B7-1 monomers | 0.03 μm2 s−1 | Ref. 4 |
| α33 | Bivalent association of B7-1 and PD-L1 | 0.17 μm2 s−1 | This work |
| δ1 | Dissociation of PD1·PDL1 complexes | 1.44 s−1 | This work |
| δ2 | Dissociation of PD1·PDL2 complexes | 0.55 s−1 | This work |
| δ3 | Dissociation of B71·PDL1 complexes | 5.94 s−1 | This work |
| δ4 | Dissociation of B7-1 dimer | 1 s−1 | Ref. 4 |
| δ33 | Dissociation of bivalent B7-1·PD-L1 complexes | 5.94 s−1 | This work |
a The motilities of the cell surface molecules were assumed to be the same as the ones observed for CD2 (50).