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Loss of GLI1 blocks PanIN progression in KC mice. A–D, pancreata at ×20 (left panels) and ×40 (right panels) magnifications. A and B, KC pancreas showing developing PanIN-2 and PanIN-3 (A) and pancreatic cancer (B). C and D, examples of the GKO/KC pancreatic phenotypes. C, representative H&E image showing PanIN-1A. D, example of the most common phenotype of the GKO/KC mice. These animals present with pancreata containing normal acini and islet structures.
