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. 2013 Mar 13;288(17):11877–11886. doi: 10.1074/jbc.M112.442491

FIGURE 3.

FIGURE 3.

Effects of manipulating LR11 levels on the hypoxia-induced adhesion of immature hematological cells. A, after incubation in hypoxic or normoxic conditions for 24 h, the numbers of attached U937 cells, either transfected with shRNA specific for LR11 (#1 or #5) or with control shRNA (Ctrl), to MSCs were determined as described under “Experimental Procedures.” Inset, LR11 levels in normal and LR11-knockdown U937 cells were analyzed by immunoblotting. Data are shown as -fold increase of those at control cells without hypoxic conditions and presented as mean ± S.D. (error bars; n = 3). *, p < 0.05; ns, not significant. B, after incubation in normoxic or hypoxic conditions for 24 h, the numbers of c-Kit+ Lin− cells prepared from LR11+/+ or LR11−/− mice attached to OP-9 cells were determined as described under “Experimental Procedures.” Data are presented as mean ± S.D. (n = 3). *, p < 0.05.