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. 2013 Mar 15;288(17):11949–11959. doi: 10.1074/jbc.M112.437764

FIGURE 4.

FIGURE 4.

PASGtYybT contains a hydrophobic pocket covered by the dynamic D-loop. A, surface representation of the PASGtYybT showing a hydrophobic pocket as the potential ligand-binding pocket. B, Thr-110- and Ile-112-containing D-loop forms a lid over the hydrophobic pocket. C and D, 1H-13C HSQC spectra indicating that the methyl groups of Thr-111 and Ile-113 adopt two conformations. E and F, 13C NOESY-HMQC strips for the major and minor conformations showing the presence/absence of water NOEs, indicating that the side chains of Thr-111 and Ile-113 can adopt solvent-exposed (major) and buried (minor) conformations.