FIGURE 5.

Class IIa HDACs modulate the expression of Tgfβ cytokines. A, qPCR for Tgfβ cytokines using RNA lysates from fibroblasts transduced as indicated. An empty vector was used as a control (Ctrl, also in C). Double asterisks indicate p value < 0.01 (also in B and C). B, qPCR for Tgfβ cytokines using RNA lysates from fibroblasts reprogrammed with OKS and either empty vector or HDAC7. D, day. Single asterisk indicates p value < 0.05. C, number of GFP+ colonies in fibroblasts reprogrammed with OKS/OKSM and HDAC7. Tgfβ3 was added as shown.