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Lack of Gpr177 leads to altered gene expression in the enamel knot. In the absence of Gpr177 in the dental epithelium, the expression levels of Shh (A, A′), Bmp2 (B, B′) Fgf4 (C, C′), Bmp4 (F, F′), and Lef1 (G, G′) in the enamel knot are reduced significantly, and the expression of Fgf9 (D, D′) and Fgf3 (E, E′) is abolished completely. However, the expression of Fgf3 (E, E′), Bmp4 (F, F′), Lef1 (G, G′), and Msx1 (H, H′) in the dental mesenchyme, although slightly reduced, is retained.
