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. Author manuscript; available in PMC: 2013 Apr 26.
Published in final edited form as: Nature. 2012 Feb 22;483(7387):47–52. doi: 10.1038/nature10835

Figure 3. Photo-stimulation of L6 suppresses cortex faster than it suppresses dLGN.

Figure 3

a. Schematic of setup.

b. Visual response of dLGN unit with (blue) and without (black) L6 photo-stimulation Scale bar, 20 spikes/s.

c. Average response of each dLGN unit with and without L6 photo-stimulation. Inset, monotonic suppression of dLGN.

d. Schematic of setup for silencing V1 by photo-stimulation of PV inhibitory neurons.

e. Visual response of dLGN unit with and without photo-silencing of V1. Scale bar, 30 spikes/s

f. Average response of each dLGN unit with and without cortical silencing.

g. Schematic of setup.

h. Left, time-course of L6-mediated suppression of dLGN (gray) and V1 (black) (n = 4). Bin size: 3 ms. Right, same data on expanded timescale. The first bin at LED onset was blanked to remove LED-induced artifact. Inset, time to suppression exceeding 2 SDs from baseline activity in dLGN and V1 (y-axis: ms) for four experiments (p = 0.012).