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. Author manuscript; available in PMC: 2013 Apr 26.
Published in final edited form as: Nature. 2012 Feb 22;483(7387):47–52. doi: 10.1038/nature10835

Figure 4. Photo-stimulation of L6 recruits intra-cortical synaptic inhibition.

Figure 4

a. Schematic of in vitro setup.

b. Average IPSCs (blue) and EPSCs (red) recorded in pyramidal cells during photo-stimulation of L6. Synaptic currents are averages of n = 5–12 cells. Inset, onset of EPSC.

c. Histogram of excitatory charge as a percentage of total charge.

d. Top traces: perforated patch recording from L5 pyramidal cell in response to depolarizing current injection with (right) and without (left) L6 photo-stimulation. Bottom graphs: spike rate with and without L6 photo-stimulation.

e. Average spike rate in control versus spike rate with L6 photo-stimulation for each cell.

f. Schematic of setup for focal photo-stimulation.

g. Top traces: spiking of L5 pyramidal cell to depolarizing current injection with focal photo-stimulation of L6 at three progressively more distant positions (left to right). Bottom graph: spike rate in control (black) and with focal photo-stimulation of L6 (blue) (n = 4). Delta indicates medial/lateral distance from radial axis through recording site.

h. Percentage of spike suppression plotted against horizontal displacement.