Table 3.
Percentage of patients with cognitive impairment* for the total sample of 51 inpatients with therapy-resistant BD depression, BD I, and BD II on nine cognitive tasks from the MCCB, six domain scores and mean composite score, and IQ and change in IQ from the estimated premorbid level
|
Neurocognitive domain |
Total sample |
BD I |
BD II |
BD I vs. BD II |
|
|---|---|---|---|---|---|
| Test | n = 51 | n = 19 | n = 32 | χ2 | p |
| Speed of processing |
43.1 |
63.2 |
31.2 |
4.9 |
0.041 |
| BACS–Symbol Coding |
49.0 |
52.6 |
46.9 |
0.2 |
0.776 |
| Fluency |
17.6 |
31.6 |
9.4 |
4.0 |
0.062 |
| TMT-A |
45.1 |
63.2 |
34.4 |
4.0 |
0.080 |
| Attention/Vigilance |
36.4a |
42.9 |
33.3 |
0.4 |
0.738 |
| CPT |
|
|
|
|
|
| Working memory |
21.6 |
21.1 |
21.9 |
0.0 |
1.000 |
| Spatial Span |
18.0b |
26.3 |
12.9 |
1.4 |
0.273 |
| Letter-Number Span |
25.5 |
31.6 |
21.9 |
0.6 |
0.515 |
| Verbal learning |
39.2 |
42.1 |
37.5 |
0.1 |
0.774 |
| HVLT-R |
|
|
|
|
|
| Visual learning |
24.5c |
38.9 |
16.1 |
3.2 |
0.094 |
| BVMT-R |
|
|
|
|
|
| Reasoning |
30.0b |
22.2 |
34.4 |
0.8 |
0.523 |
| Mazes |
|
|
|
|
|
| Mean composite score |
31.4 |
42.1 |
25.0 |
1.6 |
0.228 |
| IQ |
5.9 |
15.8 |
0.0 |
5.4 |
0.047 |
| WASI |
|
|
|
|
|
| IQ decline (NART-WASI) ≥1.5 SD | 15.2d | 33.3 | 3.6 | 7.5 | 0.010 |
*Defined as at least 1.5 SD below the normal mean.
an = 44, bn = 50, cn = 49, dn = 46 due to missing data.