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. 2013 Apr 10;13:81. doi: 10.1186/1472-6882-13-81

Table 1.

MICs of the extracts, compounds from Garcinia nobilis, Oricia suaveolens, Balsmocitrus camerunensis and reference drugs on documented strains and clinical MDR isolates

Tested samplesa Microorganisms, strains and MIC (μg/ml)b
E. coli
 E. aerogenes
 K. pneumoniae
 P. stuartii
 P. aeruginosa
 M. tuberculosis
ATCC 10536 AG 100 AG 102 ATCC 13048 CM 64 EA 27 ATCC 11296 KP55 ATCC 29916 NAE 16 PA 01 PA 124 ATCC 27294 MTCS1 MTCS2
Crude extracts
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
GNB
 64
 256
 256
 256
 512
 256
 128
 512
 512
 -
 512
 -
 128
 256
 256
OSR
 128
 512
 -
 512
 -
 -
 256
 256
 512
 256
 -
 -
 512
 -
 512
OSW
 128
 512
 -
 -
 -
 -
 128
 128
 -
 128
 -
 -
 256
 -
 512
BCB
 512
 -
 -
 256
 -
 -
 512
 512
 -
 -
 -
 -
 -
 -
 -
Compounds
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
1
 256
 128
 -
 -
 -
 -
 -
 -
 -
 -
 -
 -
 -
 -
 -
2
 64
 64
 128
 128
 256
 64
 512
 512
 256
 64
 64
 128
 8
 32
 8
3
 128
 128
 64
 256
 -
 256
 -
 -
 -
 -
 -
 -
 64
 -
 128
4
 -
 64
 128
 -
 256
 128
 -
 -
 -
 -
 256
 -
 512
 -
 512
5
 64
 128
 128
 -
 -
 512
 512
 -
 512
 -
 64
 128
 32
 64
 64
8
 512
 128
 256
 -
 512
 128
 512
 -
 -
 -
 -
 -
 128
 512
 256
9
 -
 128
 256
 -
 256
 256
 -
 -
 -
 -
 -
 -
 -
 -
 -
10
 64
 128
 256
 -
 -
 128
 -
 -
 512
 -
 -
 -
 128
 -
 512
11
 128
 256
 128
 -
 256
 512
 512
 -
 -
 -
 -
 512
 -
 -
 -
13
 512
 64
 256
 -
 512
 128
 256
 -
 -
 -
 128
 512
 256
 512
 512
15
 128
 256
 256
 -
 -
 256
 -
 -
 -
 -
 -
 -
 -
 -
 -
16
 128
 128
 -
 -
  
 512
 -
 -
 512
 -
 -
 -
 512
 -
 -
17
 -
 128
 -
 -
 -
 -
 -
 -
 -
 -
 -
 -
 -
 -
 -
18
 -
 256
 -
 -
 -
 256
 -
 -
 -
 256
 -
 -
 -
 -
 -
19
 -
 256
 -
 -
 -
 -
 -
 -
 -
 -
 -
 -
 -
 -
 -
20
 -
 512
 -
 -
 -
 -
 -
 -
 -
 -
 -
 -
 -
 -
 -
21
 512
 256
 -
 -
 -
 256
 256
 -
 -
 -
 -
 -
 -
 -
 -
22
 512
 256
 256
 512
 128
 -
 -
 512
 -
 -
 -
 -
 -
 -
 -
RA <4 16 512 64 - 64 4 32 - 64 128 128 1 128 4

aTested samples [methanol-dichloromethane 1:1 extract of the stem bark of Garcinia nobilis (GNB), the wood (OSW)roots (OSR) of Oricia suaveolens, and stem bark of Balsmocitrus camerunensis (BCB); compounds isolated from the stem bark of Garcinia nobilis (1–5), Oricia suaveolens woods (6–11) and roots (12–17), and the stem back of Balsmocitrus camerunensis (18–22); caroxanthone (1), 4-prenyl-2-(3,7-dimethyl-2,6-octadienyl)-1,3,5,8-tetrahydroxyxanthone (2), smeathxanthone A (3), 8-hydroxycudraxanthone G (4), morusignin I (5), stigma-5-en-3-ol (6), 20(29)lupen-2-ol (7), evoxanthine (8), norevoxanthine (9), 1-hydoxy-2,3-dimethoxy-10-methylacridone (10), 1,3-dimethoxy-10-methylacridone (11), kokusaginine (13), 1-hydroxy-4-methoxy-10-methylacridone (15), syringaresinol (16), limonin (17), 1-hydroxy-3,6-dimethoxy-8-methylxanthone (18), xanthoxyletin (19), imperatorin (20), 6,8-dimethoxycoumarin (21), umbelliferone (22)]; RA: reference antibiotics were chloramphenicol for bacteria, isoniazid for M. tuberculosis; b(−): MIC > 512 μg/mL.