Table 1.
Correlation between some relevant residues in E. coli CusA with the corresponding residues in the CzrA and NczA orthologs
|
CusA |
M271 |
M391 |
M403 |
M410 |
M486 |
M501 |
M573 |
M623 |
M672 |
M755 |
M1009 |
D405 |
E939 |
K984 |
|
CzrA |
L301a |
M420 |
I430 |
I437 |
L512 |
V527 |
Q598 |
A648 |
E699 |
A782 |
Q1031 |
D432 |
L972 |
V1006 |
|
NczA |
L291 |
M410 |
I420 |
I427 |
L502 |
V517 |
H588 |
V638 |
E689 |
V722 |
Q1020 |
D422 |
L961 |
V995 |
| Residue conservedb | --- (L) | M (M) | I/L (I/L) | I/V (I/V) | L (L) | ---(V/I) | --- (−−-) | --- (−−-) | E (E) | --- (−−-) | Q ( Q ) | D ( D ) | L ( L ) | V(V/I) |
aThe numbers correspond to the positions in C. crescentus CzrA and NczA proteins, respectively. The correspondence was determined by sequence alignment made using the PHYRE2 program [44].
b Conservation profile within the CzrA-like proteins and in the NczA-like proteins (in parentheses). A conserved residue was considered the residue most prevalent (more than 75% conserved) in that position within the CzcA orthologous groups. In bold and italic are shown the residues absolutely conserved and ----- is not conserved.