Table 2. Censoring information for survival study: animal n by cause of death/euthanasia for SOD1 Tg mice.
SOD1 Tg mice only | ||||
Cause of death/euthanasia | Vehicle | Erlotinib | Total | Censored? |
Loss of righting reflex (within 15s) | 14 | 25 | 39 | no |
Loss of 20% body weight (from peak weight) | 8 | 5 | 13 | no |
Both the above | 5 | 6 | 11 | no |
Found dead (possible bad injection)* | 15 (3F,12M) | 7 (4F, 3M) | 22 | yes |
Found dead (close to euthanasia)** | 4 | 3 | 7 | no |
Euthanized due to injury (skin lesions) | 0 | 1 (M) | 1 | yes |
Lost >20% peak body weight but no other critical signs | 0 | 1 (F) | 1 | yes |
Total censored | 15 (3F,12M) | 9 (5F, 4M) | 24 | |
Total uncensored | 31 (19F,12M) | 39 (19F,20M) | 70 | |
GRAND TOTAL | 46 (22F,24M) | 48 (24F,24M) | 94 |
F: female; M: male.
mouse was above critical weight and had normal righting reflex.
mouse had already shown first signs of loss of righting reflex.