Table 2.
Changes in the hematological indices in all subjects exposed to DE and Filtered Air (FA)
| Hematological indices | n |
Change from baseline to 7 h Mean ± SE |
DE effect Δ baseline - 7 h (95% CI) | n |
Change from baseline to 22 h Mean ± SE |
DE effect Δ baseline - 22 h (95% CI) | ||
|---|---|---|---|---|---|---|---|---|
| Filtered air | DE-200 | Filtered air | DE-200 | |||||
|
Leukocytes (x1000 cells/μL) |
26 |
0.4 ± 0.2 |
0.4 ± 0.2 |
-0.0 (-0.3 to 0.3) |
24 |
0.03 ± 0.1 |
0.1 ± 0.2 |
0.1 (-0.3 to 0.4) |
|
Neutrophils (x1000 cells/μL) |
24 |
0.4 ± 0.1 |
0.5 ± 0.2 |
0.0 (-0.4 to 0.4) |
24 |
0.2 ± 0.1 |
0.2 ± 0.1 |
0.1 (-0.3 to 0.4) |
|
Lymphocytes (x1000 cells/μL) |
25 |
0.03 ± 0.1 |
-0.01 ± 0.1 |
-0.04 (-0.2 to 0.1) |
23 |
-0.1 ± 0.05 |
-0.1 ± 0.04 |
-0.03 (-0.2 to 0.1) |
|
Monocytes (x1000 cells/μL) |
24 |
0.01 ± 0.02 |
-0.01 ± 0.03 |
-0.02 (-0.1 to 0.1) |
21 |
-0.03 ± 0.02 |
-0.002 ± 0.04 |
0.03 (-0.1 to 0.1) |
|
Erythrocytes (million cells/μL) |
30 |
0.1 ± 0.02 |
-0.2 ± 0.2 |
-0.2 (-0.7 to 0.2) |
28 |
0.1 ± 0.03 |
0.2 ± 0.3 |
0.1 (-0.5 to 0.7) |
|
Platelets (x1000 cells/μL) |
24 |
9.2 ± 3.4 |
11.4 ± 2.8 |
2.2 (-4.2 to 8.7) |
22 |
4.5 ± 2.9 |
10.1± 2.6 |
5.5 (-2.8 to 13.8) |
|
Hemoglobin (gm/dL) |
24 |
0.2 ± 0.1 |
0.3 ± 0.1 |
0.2 (-0.0 to 0.4) |
24 |
0.3 ± 0.1 |
0.5 ± 0.1 |
0.1 (-0.1 to 0.4) |
| Hematocrit (%) | 26 | 0.5 ± 0.3 | 1.4 ± 0.2 | 1 (0.3 to 1.6)* | 23 | 1.6 ± 0.4 | 1.1 ± 0.3 | 0.5 (-0.5 to 1.4) |
Data are shown for the absolute mean differences from pre-exposure to 7 hours (Δ Baseline-7 h) and 22 hours (Δ Baseline-22 h) of exposure initiation. DE effect refers to the effect attributable to DE calculated as [(Post –pre DE exposure - (Post-pre) FA exposure] displayed as the absolute change in each of the indices.
*Indicates a P-value of 0.008; SE represents standard error; CI – Confidence Interval.