Skip to main content
. 2013 Mar 26;10:7. doi: 10.1186/1743-8977-10-7

Table 4.

Inflammatory cytokines measured by the multiplex assay in humans exposed to DE and FA

Inflammatory cytokines N Δ Baseline -7 h [fold change ± SE] (pg/dL)
 DE Effect Δ Baseline-7 h [fold change] (95% confidence interval)
 N Δ Baseline -22 h [fold change ± SE] (pg/dL)
 DE Effect Δ Baseline-22 h [fold change] (95% confidence interval)
Filtered air DE-200 Filtered air DE-200
P-values P-values
Myeloperoxidase
 16
 0.2 ± 0.2
 0.4 ± 0.3
 0.2
 16
 0.01 ± 0.2
 0.4 ± 0.2
 0.4
(95% CI: -1.1 to 0.7)
 (95% CI: -0.2 to 0.9)
P=0.7
 P=0.2
Adiponectin
 16
 0.1 ± 0.2
 -0.02 ± 0.1
 0.1
 15
 -0.1 ± 0.2
 0.2 ± 0.1
 0.3
(95% CI: -0.4 to 0.6)
 (95% CI: -0.3 to 0.8)
P=0.6
 P=0.3
MMP-9
 14
 0.0 ± 0.1
 0.3 ± 0.2
 0.3
 15
 0.01 ± 0.1
 -0.1 ± 0.1
 -0.1
 
  
  
  
 (95% CI: -0.2 to 0.8)
  
  
  
 (95% CI: -0.6 to 0.3)
 
  
  
  
 P=0.2
  
  
  
 P=0.5
MCP-1
 15
 -0.2 ± 0.1
 -0.2 ± 0.1
 -0.01
 15
 -0.2 ± 0.1
 -0.2 ± 0.1
 -0.01
 
  
  
  
 (95% CI: -0.3 to 0.2)
  
  
  
 (95% CI: -0.2 to 0.2)
 
  
  
  
 P=0.9
  
  
  
 P=0.9
VEGF
 15
 0.1 ± 0.1
 0.1 ± 0.1
 0.02
 16
 0.1 ± 0.1
 0.1 ± 0.1
 0.01
(95% CI: -0.2 to 0.2)
 (95% CI: -0.1 to 0.1)
P=0.6
 P=0.7
Pro-BNP
 5
 0.3 ± 0.2
 -0.2 ± 0.3
 -0.4
 6
 0.1 ± 0.3
 -0.1 ± 0.3
 -0.2
(95% CI: -1.5 to 0.7)
 (95% CI: -1.0 to 0.6)
P=0.9
 P=0.1
TNF-α
 15
 -0.1 ± 0.04
 -0.1 ± 0.1
 0.02
 15
 0.0 ± 0.1
 -0.03 ± 0.1
 -0.03
 
  
  
  
 (95% CI: -1.4 to 0.2)
  
  
  
 (95% CI: -0.2 to 0.1)
 
  
  
  
 P=0.8
  
  
  
 P=0.5
IL-1β
 9
 -0.3 ± 0.2
 0.1 ± 0.1
 0.5
 11
 -0.2 ± 0.3
 0.1 ± 0.3
 0.3
 
  
  
  
 (95% CI: -0.01 to 1)
  
  
  
 (95% CI: -1.1 to 2 )
 
  
  
  
 P=0.06
  
  
  
 P=0.9
IL-6
 11
 -0.04 ± 0.1
 1.1 ± 0.7
 1.1
 8
 0.2 ± 0.1
 -0.1 ± 0.1
 -0.3
(95% CI: -0.7 to 3)
 (95% CI: -0.6 to 0.1)
P=0.6
 P=0.1
IL-8
 15
 -0.3 ± 0.1
 -0.2 ± 0.2
 0.1
 16
 -0.2 ± 0.1
 -0.3 ± 0.2
 -0.1
(95% CI: -0.3 to 0.6)
 (95% CI: -0.5 to 0.3)
P=0.8
 P=0.9
IL-10 15 -0.3 ± 0.1 -0.01 ± 0.1 0.3
 16 -0.1 ± 0.1 0.1 ± 0.1 0.2
(95% CI: -0.1 to 0.6)
 (95% CI: -0.3 to 0.6)
P=0.2 P=0.5

Data are shown for the mean log2 differences from pre-exposure to 7 hours (Δ Baseline-7 h) and 22 hours (Δ Baseline-22 h) of exposure initiation. DE effect refers to the effect attributable to DE calculated as (Post –pre DE exposure)-(Post-pre FA exposure) for the log2 transformed values to obtain fold changes. Positive difference indicates that the change in given marker was relatively more positive over DE-exposure interval, as compared to change over FA exposure interval. SE - Standard Error; CI - Confidence Interval.