Figure 4. Prostaglandin inhibition of efferocytosis involves COX-2.

U937 cells were incubated in normal RPMI media or SBC-1 supernatant that had been treated with indomethacin. Following 24 hrs incubation, an efferocytosis assay was performed. (n = 5 experiments performed in triplicate). Data presented as box plots as described in Figure 1. Values are presented as percentage of macrophages ingesting apoptotic cells *, p<0.05 compared with RPMI media treatment (one-way ANOVA, Dunnett’s test).