Table 3. List of residues at the binding interface of Hb-Hpβ complex. * .
Residue | Frequency | Residue | Frequency |
Hemoglobin α | Haptoglobin β | ||
Val1 | 8 | Ile1 | 8 |
Met76 | 8 | Leu2 | 10 |
Asp94 | 7 | Gly4 | 7 |
Pro95 | 10 | His5 | 10 |
Val96 | 7 | Leu6 | 10 |
Lys99 | 10 | Asp7 | 10 |
Lys127 | 8 | Ala8 | 10 |
Ala130 | 9 | Lys9 | 10 |
Ser131 | 10 | Ser11 | 9 |
Thr134 | 10 | Val64 | 7 |
Val135 | 8 | Glu99 | 8 |
Ser138 | 10 | Arg125 | 10 |
Lys139 | 9 | Lys130 | 10 |
Tyr140 | 8 | Phe131 | 10 |
Arg141 | 10 | Thr132 | 10 |
Asp133 | 10 | ||
Hemoglobin β | His134 | 10 | |
Pro36 | 8 | Lys136 | 10 |
Trp37 | 10 | Tyr137 | 9 |
Arg40 | 10 | Pro158 | 8 |
Phe41 | 10 | Lys160 | 10 |
Asp94 | 8 | Lys161 | 7 |
His97 | 10 | Gln186 | 10 |
Asp99 | 10 | Glu187 | 10 |
Pro100 | 10 | Asp188 | 7 |
Glu101 | 10 | Tyr191 | 10 |
Asn139 | 10 | Lys218 | 8 |
Ala142 | 9 | Val222 | 8 |
His143 | 10 | ||
Lys144 | 10 | ||
Tyr145 | 10 | ||
His146 | 10 |
Residues in bold text are those also found in the Hb-Hp complex.