Table 2.
Selected studies measuring serum CRP before and after CPAP
| Study | Study design | Study population characteristics | OSA definition | Minimum CPAP usage | Outcome |
|---|---|---|---|---|---|
| Carniero et al. 2009 [63] |
Case–control |
7 severely obese men |
AHI > 30 |
≥ 5 h/day for 3 months |
No significant change |
| Chung et al. 2011 [64] |
Case–control |
25 total: 22 men, 3 women |
AHI ≥15 |
≥ 4 h/day for 3 months |
No significant change |
| Colish et al. 2012 [65] |
Case–control |
47 total: 32 men, 15 women; 25 obese, 22 overweight |
AHI ≥ 15 |
≥ 4.5 h/day for 12 months |
No significant change |
| Dorkova et al. 2008 [66] |
Case–control |
16 total: 15 men, 1 woman |
AHI ≥ 30 |
≥ 4 h/day for 8 weeks |
No significant change |
| Harsch et al. 2004 [67] |
Case–control |
20 obese patients |
AHI = 48.6 ± 9.1 (mean ± SD) |
5.32 ± 0.67 h/day (mean ± SD) for 8 weeks |
No significant change |
| Iesato et al. 2007 [68] |
Case–control |
36 total |
AHI ≥ 20 |
≥ 4 h/day for 3 months |
Significantly decreased |
| Ishida et al. 2009 [69] |
Case–control |
40 total: 32 men, 8 women |
AHI > 20 |
> 4 h/day, 5d/week for 6 months |
Significantly decreased |
| Patruno et al. 2007 [58] (APAP) |
Case–control |
15 total |
AHI > 20 |
> 4 h/day for 3 months |
Significantly decreased |
| Patruno et al. 2007 [58] (CPAP) |
Case–control |
16 total |
AHI > 20 |
> 4 h/day for 3 months |
Significantly decreased |
| Ryan et al. 2007 [70] |
Case–control |
49 total |
AHI > 15 |
> 4 h/day for 6 weeks |
No significant change |
| Schiza et al. 2010 [61] |
Case–control |
436 total: 252 men, 184 women |
AHI > 15 |
> 4 h/day, 5d/week for 12 months |
Significantly decreased |
| Steiropoulos et al. 2007 [71] |
Case–control |
20 total: 16 men, 4 women |
AHI > 15 |
≥ 4 h/night for 6 months |
Significantly decreased |
| Yokoe et al. 2003 [18] |
Case–control |
17 total |
AHI ≥ 20 |
1 month |
Significantly decreased |
| Zhao et al. 2011 [72] | Case–control | 27 total | AHI ≥ 30 | Good compliance for 3 months | Significantly decreased |