Table 1.
Clinical and immunophenotypic features of T-ALL patients at diagnosis according to expression of miR-221 and miR-374
|
Patient characteristics |
miR-221 |
|
miR-374 |
|
||
|---|---|---|---|---|---|---|
| High expression | Low expression | P-value | High expression | Low expression | P-value | |
| Age1, years |
22.8 (1 – 66) |
17.4 (2 – 44) |
0.22 |
23.6 (1 – 66) |
16.8 (2 – 44) |
0.49 |
| Gender (M/F) |
24(18/6) |
24 (21/3) |
0.46 |
24(21/3) |
23(17/6) |
0.12 |
| Mediastinal mass (%) |
14/24(58) |
6/24 (25) |
0.15 |
15/24 (62.5) |
5/23(22) |
0.13 |
| Lymphadenopathy (%) |
15/24(62.5) |
21/24 (87.5) |
0.26 |
16/24 (67) |
19/23(83) |
0.24 |
| Splenomegaly (%) |
16/24(67) |
16/24 (67) |
0.66 |
17/24 (71) |
14/23(61) |
0.6 |
| Hepatomegaly (%) |
15/24(62.5) |
16/24 (67) |
0.99 |
17/24 (71) |
13/23(56.5) |
0.44 |
| CNS involvement (%) |
1/24(4) |
2/24 (8) |
0.56 |
2/24 (8) |
1/23(4) |
0.53 |
| Blasts BM1 (%) |
77.3 (20 – 100) |
90.5 (28 – 100) |
0.09 |
77.6 (20 – 100) |
90.7 (28 – 100) |
0.64 |
| Blasts PB1 (%) |
63.4 (0 – 100) |
78.5 (10 – 100) |
0.18 |
61.5 (0 – 100) |
86 (10 – 100) |
0.45 |
| Hemoglobin1 (g/l) |
10.4 (3.6 – 15.6) |
10.4 (4.6 – 17.1) |
0.97 |
10.1 (3.6 – 15.8) |
10.8 (5.3 – 17.1) |
0.4 |
| WBC1 count × 109/l |
104 (4.6 – 314) |
202.3 (4.5 – 790) |
0.06 |
118 (4.5 – 781) |
196 (18 – 789) |
0.61 |
| Platelets1 × 109/l |
149.4 (9 – 652) |
48.8 (9 – 185) |
0.009* |
140 (9 – 652) |
55.8 (9 – 231) |
0.03* |
| Pre thymic (%) |
7/24(29) |
4/24(17) |
0.31 |
6/24 (25) |
5/23(22) |
0.81 |
| Thymic (%) |
7/24(29) |
10/24(42) |
0.54 |
9/24 (37.5) |
7/23(30) |
0.51 |
| Mature T (%) |
8/24(33) |
8/24(33) |
0.98 |
7/24 (29) |
9/23(39) |
0.37 |
| CD34 (%) |
16/24(67) |
8/24(33) |
0.042* |
13/24 (54) |
11/23(48) |
0.56 |
| CD56 (%) |
11/24(46) |
1/24(4) |
0.001* |
12/24 (50) |
1/23(4) |
<0.001* |
| TdT (%) | 18/24(75) | 21/24(87) | 0.46 | 17/24 (71) | 21/23(91) | 0.28 |
CNS: central nervous system; WBC: white blood cell; PB: peripheral blood; BM: bone marrow; cCD3: cytoplasmic CD3; sCD3: surface CD3; TdT: terminal deoxynucleotidyl transferase. *Significant P-value.
1 Values represent mean (range).