Table 2.
Univariate and multivariate analyses for CR, OS, and DFS in 48 patients with T-ALL
|
End point |
Model variables |
Univariate analysis |
Multivariate analysis |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| HR | OR | 95% CI | P-value | HR | OR | 95% CI | P-value | ||||
| CR |
miR-221 expression (low vs high) |
|
0.63 |
0.17 |
2.39 |
0.507 |
|
1.71 |
0.26 |
10.9 |
0.571 |
| |
WBC counts (≤ 30×109/L vs > 30×109/L) |
|
1.55 |
0.32 |
7.41 |
0.581 |
|
0.92 |
0.11 |
7.15 |
0.94 |
| |
Age at diagnosis (≤ 15 vs > 15) |
|
1.68 |
0.43 |
6.54 |
0.454 |
|
2.63 |
0.53 |
12.9 |
0.234 |
| |
CD56 expression (CD56-vs CD56+) |
|
0.33 |
0.08 |
1.38 |
0.133 |
|
0.14 |
0.01 |
1.2 |
0.073 |
| OS |
miR-221 expression (low vs high) |
3.17 |
|
1.45 |
6.92 |
0.004 |
2.31 |
|
0.92 |
5.81 |
0.074 |
| |
WBC counts (≤ 30x109/L vs > 30×109/L) |
0.69 |
|
0.29 |
1.64 |
0.412 |
1.41 |
|
0.53 |
3.7 |
0.481 |
| |
Age at Diagnosis (≤ 15 vs > 15) |
2.19 |
|
0.98 |
4.85 |
0.05 |
2.2 |
|
0.96 |
5 |
0.059 |
| |
CD56 expression (CD56-vs CD56+) |
2.99 |
|
1.37 |
6.51 |
0.006 |
2.04 |
|
0.76 |
5.46 |
0.155 |
| DFS |
miR-221 expression (low vs high) |
1.87 |
|
0.89 |
3.92 |
0.093 |
1.54 |
|
0.57 |
4.17 |
0.391 |
| |
WBC counts (≤ 30×109/L vs > 30×109/L) |
1.76 |
|
0.81 |
3.82 |
0.148 |
1.81 |
|
0.65 |
5.01 |
0.25 |
| |
Age at diagnosis (≤ 15 vs > 15) |
0.77 |
|
0.37 |
1.6 |
0.488 |
0.89 |
|
0.42 |
1.9 |
0.778 |
| CD56 expression (CD56-vs CD56+) | 2.73 | 1.03 | 7.18 | 0.041 | 2.25 | 0.69 | 7.28 | 0.173 | |||
Abbreviations: OS: overall survival; DFS: disease-free survival; CR: complete remission; HR, Hazard ratio; OR: odds ratio; WBC: white blood count.