Table 4.
Multivariable adjusted odd ratios (and 95% confidence intervals) for the determinants of CKD stage 3-5
| Variables | MDRD | MDRD corrected | CKD-EPI | CKD-EPI corrected | Cockroft-Gault |
|---|---|---|---|---|---|
| Age (/year) |
1.09 (1.08-1.11) |
1.11 (1.09-1.14) |
1.14 (1.11-1.15) |
1.14 (1.11-1.17) |
1.21 (1.18-1.25) |
| Female gender |
2.88 (1.92-4.38) |
2.15 (1.18-4.14) |
2.15 (1.36-3.47) |
1.97 (1.07-3.83) |
1.43 (0.84-2.45) |
| Cohort |
0.27 (0.16-0.44) |
0.50 (0.21-1.04) |
0.39 (0.22-0.68) |
0.31 (0.10-0.73) |
0.30 (0.14-0.60) |
| Known hypertension |
1.96 (1.35-2.90) |
2.42 (1.28-4.94) |
1.97 (1.25-3.15) |
2.34 (1.20-4.93) |
2.76 (1.56-5.00) |
| Triglycerides (/mmol/L) |
NS |
1.33 (1.04-1.67) |
NS |
1.33 (1.00-1.71) |
NS |
| Body mass index (/kg/m2) |
NS |
NS |
NS |
NS |
0.81 (0.77-0.85) |
| Total cholesterol (/mmol/L) | NS | NS | 1.19 (1.02-1.39) | NS | NS |
CKD-EPI, Chronic Kidney Disease Collaboration Epidemiology; 4-v-MDRD, four variable Modification of Diet in Renal Disease.
For CKD-EPI, TC was only significant when triglycerides (NS) was removed from the model, however triglycerides in the presence of other covariates except total cholesterol was not significant. For Cockroft-Gault: Hip was significant when replacing waist circumference in the models, not in its presence. And hypertension was significant only in the presence of body mass index in the model.