Table 2.
Statistically significant associations of serum phosphatidylcholine species with metabolic syndrome*
| PtdCho species | Subjects With etS (pmol/ml) |
Subjects Without MetS (pmol/ml) |
b (MetS) |
p (MetS) |
b (Factor1) |
p (Factor1) |
||
|---|---|---|---|---|---|---|---|---|
| Mean | SE | Mean | SE | |||||
| PtdCho 30:0 | 2728.5 | 55.1 | 2182.7 | 40.0 | 0.2098 | 1.02×10−5 | 0.0921 | 0.0001 |
| PtdCho 32:0 | 9027.9 | 90.4 | 8310.9 | 58.9 | 0.2031 | 4.39 ×10−6 | 0.1022 | 8.87 ×10−6 |
| PtdCho 32:1 | 25931.9 | 451.1 | 20645.0 | 313.5 | 0.3409 | 1.92 ×10−11 | 0.2066 | 1.05 ×10−16 |
| PtdCho 32:2 | 9820.5 | 107.6 | 8390.6 | 79.5 | 0.2096 | 1.78E ×10−4 | 0.0899 | 0.0019 |
| PtdCho 34:1 | 125628.9 | 915.6 | 117564.8 | 802.4 | 0.1272 | 0.0061 | 0.0845 | 0.0003 |
| PtdCho 34:5 | 65.9 | 2.1 | 50.7 | 1.3 | 0.1186 | 0.0117 | 0.0781 | 0.0013 |
| PtdCho 36:4b | 91234.3 | 1109.7 | 81877.7 | 731.9 | 0.1658 | 0.0003 | 0.0815 | 0.0009 |
| PtdCho 36:5 | 14164.9 | 301.8 | 11469.2 | 197.4 | 0.1876 | 0.0002 | 0.0992 | 0.0001 |
| PtdCho 38:2 | 12164.4 | 159.8 | 11377.7 | 111.9 | −0.0346 | 0.4633 | −0.0790 | 0.0017 |
| PtdCho 38:3 | 54563.3 | 711.9 | 44511.5 | 506.2 | 0.2871 | 1.84 ×10−8 | 0.1574 | 1.16 ×10−9 |
| PtdCho 38:6a | 503.2 | 7.6 | 477.0 | 5.3 | −0.0455 | 0.3161 | −0.0928 | 0.0001 |
| PtdCho 38:7 | 1619.6 | 25.9 | 1507.3 | 18.5 | −0.0668 | 0.1598 | −0.0868 | 0.0006 |
| PtdCho 40:6 | 13436.8 | 188.5 | 11910.5 | 137.7 | 0.1139 | 0.0132 | 0.0969 | 0.0001 |
| PtdCho 40:7 | 4151.1 | 64.8 | 4263.5 | 47.4 | −0.1598 | 0.0003 | −0.1297 | 2.13 ×10−8 |
| PtdCho 33:2 | 3909.6 | 49.1 | 3604.6 | 37.3 | 0.0094 | 0.8422 | −0.0906 | 0.0003 |
| PtdCho 35:2 | 698.5 | 8.7 | 719.9 | 6.1 | −0.1281 | 0.0029 | −0.1357 | 9.48 ×10−10 |
| PtdCho 35:3 | 1811.7 | 23.7 | 1721.2 | 16.8 | −0.0736 | 0.1034 | −0.0914 | 0.0001 |
| PtdCho 37:4 | 352.7 | 5.1 | 354.2 | 3.5 | −0.0471 | 0.2710 | −0.0844 | 0.0002 |
| PtdCho 37:6 | 391.1 | 7.5 | 366.2 | 5.8 | −0.0530 | 0.2542 | −0.0914 | 0.0002 |
| PtdCho 39:6 | 962.8 | 16.9 | 1008.4 | 12.9 | −0.1386 | 0.0016 | −0.1120 | 8.36 ×10−7 |
| Total PtdCho | 1219153.5 | 3345.9 | 1127739.2 | 2376.5 | 0.0079 | 5.8×10−7 | 0.0062 | 3.1×10−11 |
metabolic syndrome was defined in two ways: i) MetS, as a dichotomous trait based on the International Diabetes Federation definition and ii) Factor1, as the first principal component scores derived from the following nine traits – fasting glucose, fasting insulin, waist circumference, body mass index, systolic blood pressure, diastolic blood pressure, total serum cholesterol, serum triglycerides and serum high-density lipoprotein concentration. Statistically significant results using Li and Ji’s method are shown in bold.
PtdCho, phosphatidylcholine; b, regression coefficient; p, significance value
Note: For dichotomous traits (e.g. MetS) SOLAR returns a negative regression coefficient which indicates an increased risk of the dichotomous trait. For consistency of presentation, here we presented the regression coefficients for an inverted MetS trait. Full results for all 45 phosphatidylcholine species are provided in Supplementary Table 2 and they include the goodness-of-fit of each model.