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. Author manuscript; available in PMC: 2013 Apr 26.
Published in final edited form as: Oncogene. 2012 Jun 4;32(17):2230–2238. doi: 10.1038/onc.2012.229

Figure 7. bcat* increases the metastatic potential of murine melanoma.

Figure 7

(A) The lungs of the Nras and Nras;bcat* mice that developed primary melanoma were investigated for distant metastases. (p-value = 0.28, Fisher’s exact test).

(B) The number of nude mice with multiple lung tumours was scored after the injection of 2.5 × 105 cells from Nras or Nras;bcat* tumours into the tail vein. χ2 = 0.043.

(C) Mean number of lung metastases per nude mouse presenting with lung tumours after the injection of Nras or Nras;bcat* melanoma cells into the tail vein (p-value = 0.024).

(D) Lungs from nude mice, following the injection of cells from Nras or Nras;bcat* tumours into the tail vein. Arrows show melanoma tumours. The lungs shown were removed from mice about 100 days after the injection of Nras or Nras;bcat* cells. OCT was injected into the lungs to facilitate the visualisation and preservation of lung tissue.