Data source
|
German Perinatal Survey
|
Pediatrix Medical Group hospitals
|
Canadian national file
|
Australian National Perinatal Statistics Unit
|
Scottish maternity data collection
|
Italian Neonatal Study
|
WHO multicentre growth reference study
|
Sample size
|
2,300,000
|
130,111
|
676,605
|
734,145
|
100,133
|
45,462
|
882
|
n < 30 weeks
|
14146
|
11377
|
3247
|
3193
|
2053
|
623
|
N/A
|
Lowest gestational age
|
22
|
23
|
22
|
20
|
24
|
23
|
term
|
Dates
|
1995 to 2000
|
1998 to 2006
|
1994 to 1996
|
1991 to 1994
|
1998 to 2003
|
2005 to 2007
|
1997-2003
|
Data
|
Weight
|
Weight, head, length
|
Weight
|
Weight
|
Weight
|
Weight, head, length
|
Weight, head, length
|
Exclusion criteria
|
None stated, included both live and stillborn
|
Multiple births, congenital anomalies, death before discharge, outlier measures (> 2 x interquartile range below the first and 3rd quartile).
|
Ontario province was excluded due to problems with data quality.
|
Omitted multiple and still births (births < 400 grams did not need to be recorded)
|
Multiple births, lethal anomalies, weights < 250 grams, and outlier measures (> 2 x interquartile range outside the first and 3rd quartile).
|
Multiple births, stillbirths, major congenital anomalies, and fetal hydrops
|
Maternal smoking, not breastfeeding, solids before 4 months. Screened for environmental or economic constraints.
|
Method to assess gestational age
|
Ultrasound assessment 8–14 weeks and Naegle’s rule.
|
Neonatologist assessment
|
“early ultrasound has increasingly been the basis for gestational age assessments in recent years”
|
Dates, prenatal, or postnatal assessment
|
Clinician assessment based on ultrasound, maternal dates, and clinical estimates
|
Ultrasound assessment first trimester
|
Not stated
|
Outliers/smoothing method |
Cubic regression, LOESS smoothing, LMS parameter smoothing |
LMS methods, with the skew set to one and further manual smoothing |
Assumed a log normal distribution of birthweight at each gestational age and compared the probabilities of accurate versus misclassification of infant’s gestational age |
Omitted outlier measures (> 2 x interquartile range below the first and 3rd quartile). |
Cubic spline fitting |
Generalized logistic functions |
Omitted outliers > 3 SD, LMS parameter smoothing, skew set to one for weight, cubic spline fitting. |