Table 3.
Baseline characteristics of study participants in the 183 included articles
| All studies (n=183) | Longitudinal studies (n=20) | Cross-sectional studies (n=163) | P value | ||||
|---|---|---|---|---|---|---|---|
|
Baseline demographics |
|
|
|
|
|
|
|
| Median number of patients |
32 |
(21 to 53) |
31 |
(16 to 36) |
34 |
(22 to 55) |
0.058 |
| Mean age (years) |
63.5 |
(5.6) |
63.7 |
(6.7) |
63.4 |
(5.5) |
0.771 |
| Mean percentage male |
58.7 |
(13.9) |
67.3 |
(15.6) |
57.7 |
(13.3) |
0.002 |
| Median disease duration (years) |
5.7 |
(3.6 to 7.4) |
3.2 |
(1.7 to 5.9) |
5.9 |
(4.1 to 7.6) |
0.005 |
| Median percentage treated |
76.8 |
(51.2 to 88.8) |
40.6 |
(0.0 to 71.1) |
78.5 |
(56.7 to 90.2) |
0.005 |
|
Baseline disease severity |
|
|
|
|
|
|
|
| Median total UPDRS |
33.3 |
(29.4 to 40.6) |
31.8 |
(30.1 to 38.7) |
33.3 |
(29.4 to 40.6) |
0.790 |
| Median UPDRS (II) |
14.7 |
(11.6 to 16.3) |
9.1 |
(Insufficient data for IQR) |
14.8 |
(11.9 to 16.6) |
0.023 |
| Median UPDRS (III) |
21.0 |
(16.6 to 26.3) |
22.4 |
(16.3 to 28.5) |
20.9 |
(16.8 to 25.8) |
0.864 |
| Median Hoehn & Yahr |
2.5 |
(2.0 to 2.8) |
1.8 |
(1.6 to 2.0) |
2.5 |
(2.1 to 2.9) |
<0.001 |
| Median MMSE | 25.8 | (23.0 to 28.1) | 25.5 | (22.3 to 28.3) | 25.8 | (23.0 to 28.1) | 1.000 |
Means are presented with standard deviations, and medians with interquartile ranges (IQR). The P value column relates to comparisons made between longitudinal and cross-sectional studies using the Mann–Whitney test.