Table 4.
MicroRNAs significantly altered (>1.5 fold) in ALDH1(+) cells compared with ALDH1 (−) cells in ovarian cancer
| Name | Absolute fold change | P-value | Chromosome | Putative target genes |
|---|---|---|---|---|
| hsa-miR-424 |
1.98 |
0.02 |
Xq26.3 |
WEE1, CDCA4, USP15, LATS2, HIPK2 |
| hsa-miR-346 |
1.95 |
0.01 |
10q23.2 |
PTPN18, LIF |
| hsa-miR-503 |
1.86 |
0.05 |
Xq26.3 |
CDCA4 |
| hsa-miR-27a |
1.66 |
0.03 |
19p13.13 |
GSPT1, CDS1, TAB3, SFRP1, MDM4, PRKCB, SESN2, FOSB, SMAD2 |
| hsa-miR-23b |
1.53 |
0.02 |
9q22.32 |
APAF1, PPP2R5E, PPP1CB, PPIF, REPS2, CHUK |
| hsa-miR-27b | 1.50 | 0.03 | 9q22.32 | GSPT1, CDS1, TAB3, PRKCB |
The target genes presented are predicted using the TargetScan (http://www.targetscan.org) and PicTarVert (http://pictar.mdc-berlin.de) softwares.