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. 2013 Apr 10;9:68. doi: 10.1186/1746-6148-9-68

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Copyright © 2013 Lu et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Intra-articular HA-DOX hydrogel injections reduced the attenuated microscopic appearance of femoral condyles in OA. Histological examinations of hematoxylin and eosin stained sections of the cartilage in the femoral condyles at 150X (left panels) and 300X (right panels) magnifications. The samples from the groups were treated with NT (A), HA (B), DOX (C), and HA-DOX hydrogel groups (D) separately. The normal-young group (13-week-old rabbits) (E) and the normal-old group (40-week-old rabbits) (F) did not receive intra-articular treatments. The various features of OA pathology were scored on a scale of 0 to 4, with 4 representing OA lesions of the worst possible severity (G), as described in the Materials and methods. The results were compared to evaluate differences between the NT group (p < 0.05, a); the DOX group (p < 0.05, b); and the HA group (p < 0.05, c).