Table 1.
Demographic and clinical characteristics of all HCC patients and comparison of viral-HCC vs. viral marker negative HCC
|
ALL HCC cases |
Comparison of viral-HCC vs. viral marker negative HCC mean ± SD/% |
|||
|---|---|---|---|---|
|
n = (645), mean ± SD/% |
|
|
|
|
| Viral-HCC (n = 546) | Viral marker negative HCC (n = 99) | P value | ||
|
Age(years) |
56.93 ± 11.15 |
56.46 ± 10.85 |
59.57 ± 12.45 |
0.01 |
|
Gender |
|
|
|
|
| Female |
29.1 |
29.9 |
25.3 |
0.34 |
| Male |
70.9 |
70.1 |
74.7 |
|
|
BMI (Kg/m2) |
|
|
|
|
| <18 |
6.2 |
5.5 |
10.1 |
|
| 18-22.9 |
28.1 |
28.6 |
25.3 |
0.24 |
| 23-24.9 |
23.6 |
22.9 |
27.3 |
|
| ≥25 |
42.2 |
43.0 |
37.4 |
|
|
Diabetes Mellitus |
|
|
|
|
| No |
59.8 |
61.7 |
49.5 |
0.02 |
| Yes |
40.2 |
38.3 |
50.5 |
|
|
Hypertension |
|
|
|
|
| No |
65.6 |
66.8 |
58.6 |
0.11 |
| Yes |
34.4 |
33.2 |
41.4 |
|
|
Dyslipidemia |
|
|
|
|
| No |
97.5 |
97.4 |
98.0 |
0.74 |
| Yes |
2.5 |
2.6 |
2.0 |
|
|
Child score |
9.29 ± 2.31 |
9.27 ± 2.29 |
9.40 ± 2.43 |
0.59 |
|
Child class |
|
|
|
|
| A |
12.6 |
12.8 |
11.1 |
0.50 |
| B |
42.3 |
43.0 |
38.4 |
|
| C |
45.1 |
44.1 |
50.5 |
|
|
Okuda class |
|
|
|
|
| I |
14.3 |
14.3 |
14.1 |
0.97 |
| II |
61.4 |
61.5 |
60.6 |
|
| III |
24.3 |
24.2 |
25.3 |
|
|
Complication of CLD |
|
|
|
|
| No |
25.6 |
26.2 |
22.2 |
0.39 |
| Yes |
74.4 |
73.8 |
77.8 |
|
|
Hyperspleenism |
|
|
|
|
| No |
37.8 |
36.6 |
44.4 |
0.14 |
| Yes |
62.2 |
63.4 |
55.6 |
|
|
Ascites |
|
|
|
|
| No |
31.5 |
31.3 |
32.3 |
0.84 |
| Yes |
68.5 |
68.7 |
67.7 |
|
|
PSE |
|
|
|
|
| No |
65.9 |
66.8 |
60.6 |
0.23 |
| Yes |
34.1 |
33.2 |
39.4 |
|
|
Esophageal varices |
|
|
|
|
| No |
47.0 |
46.3 |
50.5 |
0.44 |
| Yes |
53.0 |
53.7 |
49.5 |
|
|
Upper GI bleed |
|
|
|
|
| No |
59.5 |
59.2 |
61.6 |
0.64 |
| Yes |
40.5 |
40.8 |
38.4 |
|
|
Hepatohydrothorax |
|
|
|
|
| No |
91.0 |
91.4 |
88.9 |
0.43 |
| Yes |
9.0 |
8.6 |
11.1 |
|
|
Hepatorenal syndrome |
|
|
|
|
| No |
77.4 |
77.8 |
74.7 |
0.50 |
| Yes |
22.6 |
22.2 |
25.3 |
|
|
Hepatopulmonary syndrome |
|
|
|
|
| No |
92.2 |
92.9 |
88.9 |
0.19 |
| Yes |
7.8 |
7.1 |
11.1 |
|
|
Total Bilirubin(mg/dl) |
|
|
|
|
| <2 |
50.2 |
50.7 |
47.5 |
0.48 |
| 2-3 |
20.5 |
20.9 |
18.2 |
|
| >3 |
29.3 |
28.4 |
34.3 |
|
|
Albumin(mg/dl) |
|
|
|
|
| >3.5 |
8.1 |
7.7 |
10.1 |
0.73 |
| 2.8-3.5 |
29.3 |
29.5 |
28.3 |
|
| <2.8 |
62.6 |
62.8 |
61.6 |
|
|
ALT (IU/ml) |
|
|
|
|
| Normal |
30.23 |
28.4 |
40.4 |
0.19 |
| Elevated |
69.77 |
71.6 |
59.6 |
|
|
Prothrombin time(seconds) |
|
|
|
|
| No |
92.2 |
92.9 |
88.9 |
0.19 |
| Yes |
7.8 |
7.1 |
11.1 |
|
|
Total Bilirubin(mg/dl) |
|
|
|
|
| <2 |
50.2 |
50.7 |
47.5 |
0.48 |
| 2-3 |
20.5 |
20.9 |
18.2 |
|
| >3 |
29.3 |
28.4 |
34.3 |
|
|
Albumin(mg/dl) |
|
|
|
|
| >3.5 |
8.1 |
7.7 |
10.1 |
0.73 |
| 2.8-3.5 |
29.3 |
29.5 |
28.3 |
|
| <2.8 |
62.6 |
62.8 |
61.6 |
|
|
ALT (IU/ml) |
|
|
|
|
| Normal |
30.23 |
28.4 |
40.4 |
0.19 |
| Elevated |
69.77 |
71.6 |
59.6 |
|
|
Prothrombin time(seconds) |
|
|
|
|
| <3 |
42.8 |
41.6 |
49.5 |
0.14 |
| 3-6 |
34.6 |
36.1 |
26.3 |
|
| >6 |
22.6 |
22.3 |
24.2 |
|
|
Platelets counts(109/L) |
165.91 ± 107.02 |
155.72 ± 96.33 |
222.12 ± 141.01 |
<0.001 |
|
AFP(IU/ml) |
|
|
|
|
| ≤200 |
58.8 |
58.2 |
61.6 |
0.30 |
| >200 | 41.2 | 41.8 | 38.4 | |