Table 3.
Univariate analysis for prognostic factors of viral-HCC vs. viral marker negative HCC
| Variables | OR(95% CI) | P value | Variables | OR(95% CI) | P value |
|---|---|---|---|---|---|
|
Age(years) |
1.026(1.01-1.05) |
0.01 |
Hepatopulmonary Syndrome |
|
|
|
Gender |
|
No |
1.0 |
0.19 |
|
| Female |
1.0 |
0.34 |
Yes |
1.62(0.80-3.29) |
|
| Male |
1.26(0.77-2.05) |
|
Total Bilirubin(mg/dl) |
|
|
|
BMI (Kg/m2) |
|
<2 |
1.0 |
0.48 |
|
| 18-22.9 |
1.0 |
0.24 |
2-3 |
0.93(0.51-1.67) |
|
| <18 |
2.08(0.90-4.77) |
|
>3 |
1.29(0.79-2.09) |
|
| 23-24.9 |
1.34(0.74-2.43) |
|
Albumin(mg/dl) |
|
|
| ≥25 |
0.98(0.56-1.69) |
|
>3.5 |
1.0 |
0.73 |
|
Diabetes Mellitus |
|
2.8-3.5 |
0.73(0.32-1.62) |
|
|
| No |
1.0 |
0.02 |
<2.8 |
0.74(0.35-1.56) |
|
| Yes |
1.64(1.07-2.53) |
|
ALT (IU/ml) |
|
|
|
Hypertension |
|
Normal |
1.0 |
0.19 |
|
| No |
1.0 |
0.11 |
Elevated |
0.58(0.37-0.91) |
|
| Yes |
1.42(0.92-2.21) |
|
Prothrombin time(second) |
|
|
|
Dyslipidemia |
|
<3 |
1.0 |
0.14 |
|
| No |
1.0 |
0.74 |
3-6 |
0.61(0.3-1.02) |
|
| Yes |
0.74(0.17-3.50) |
|
>6 |
0.91(0.53-1.55) |
|
|
Child score |
1.02(0.93-1.12) |
0.59 |
Platelets counts (109/L) |
1.01(1.0-1.01) |
<0.001 |
|
Child class |
|
AFP(IU/ml) |
|
||
| A |
1.0 |
0.50 |
≤200 |
1.0 |
0.53 |
| B |
1.02(0.50-2.11) |
|
>200 |
0.86(0.56-1.34) |
|
| C |
1.32(0.65-2.67) |
|
Duration between diagnosis of cirrhosis |
|
|
|
Okuda class |
|
00 |
2.90(1.43-5.88) |
<0.001 |
|
| I |
1.0 |
0.97 |
1-55 |
1.10(0.51-2.40) |
|
| II |
0.99(0.52-1.87) |
|
>55 |
1.0 |
|
| III |
1.15(0.51-2.15) |
|
Mode of diagnosis |
|
|
|
Complication of CLD |
|
On screening |
1.0 |
0.001 |
|
| No |
1.0 |
0.39 |
Incidental |
15.36(1.93-122.14) |
|
| Yes |
1.24(0.74-2.07) |
|
Symptomatic |
9.82(1.34-72.01) |
|
|
Hyperspleenism |
|
Stage of HCC |
|
||
| No |
1.0 |
0.14 |
Non-Advance |
1.0 |
<0.001 |
| Yes |
0.72(0.46-1.11) |
|
Advance |
3.08(1.79-5.28) |
|
|
Ascites |
|
Macroscopic types of HCC |
|
||
| No |
1.0 |
0.84 |
Solitary |
1.0 |
0.04 |
| Yes |
0.95(0.60-1.51) |
|
Paucifocal (≤ 3 nodules) |
1.04(0.62-1.73) |
|
|
PSE |
|
Multifocal(>3 nodules) |
1.38(0.73-2.63) |
|
|
| No |
1.0 |
0.23 |
Massive/infiltrative |
2.7(1.28-5.69) |
|
| Yes |
1.31(0.84-2.03) |
|
Maximum tumor size(cm) |
|
|
|
Esophageal Varices |
|
< 5 |
1.0 |
<0.001 |
|
| No |
1.0 |
|
5-10 |
2.08(1.39-3.75) |
|
| Yes |
0.84(0.55-1.29) |
0.44 |
>10 |
5.46(3.01-9.93) |
|
|
Upper GI bleed |
|
Hepatic Lobes |
|
||
| No |
1.0 |
|
Left |
1.0 |
0.98 |
| Yes |
0.90(0.58-1.40) |
0.64 |
Right |
1.05(0.53-2.06) |
|
|
Hepatohydrothorax |
|
Both |
1.03(0.49-2.16) |
|
|
| No |
1.0 |
0.43 |
Porto Venous Thrombosis |
|
|
| Yes |
1.32(0.66-2.65) |
|
No |
1.0 |
0.33 |
|
Hepatorenal Syndrome |
|
Yes |
1.25(0.788-2.00) |
|
|
|
Extra hepatic spread |
|
||||
| No |
1.0 |
0.50 |
No |
1.0 |
0.12 |
| Yes | 1.18(0.72-1.94) | Yes | 1.58(0.89-2.81) | ||