Table 5.
Comparison of viral marker negative HCC with HCV-HCC, HBV-HCC, combination-HCC
| |
Percentages |
Unadjusted OR(95% CI) |
Adjusted OR(95% CI) |
|||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Variable | HCV | HBV | Combination | NBN | HBV | Combination | NBNC | HBV | NBNC | Combination |
|
Gender |
|
|
|
|
|
|
|
|
|
|
| Female |
35.6 |
17.6 |
17.9 |
25.3 |
1 |
|
|
1 |
|
|
| Male |
64.4 |
82.4 |
82.1 |
74.7 |
2.5 (1.5-4.3) |
2.5 (1.2-5.1) |
1.6 (0.9-2.6) |
2.3 (1.3-3.8) |
1.5 (0.8-2.5) |
2.6 (1.2-5.3) |
|
Diagnosis of HCC |
|
|
|
|
|
|
|
|
|
|
| On screening |
11.9 |
2.5 |
1.9 |
1.0 |
1 |
|
|
1 |
|
|
| incidental |
8.1 |
9.2 |
5.4 |
13.1 |
5.3 (1.3-20.9) |
0.88 (0.19-3.96) |
19.06 (2.3-153.5) |
3.4 (0.8-13.9) |
10.1 (1.2-84.7) |
0.8 (0.17-3.8) |
| symptomatic |
80.1 |
88.2 |
85.7 |
85.9 |
5.1 (1.5-17.0) |
1.4 (0.53-3.76) |
12.5 (1.7-92.7) |
4.1 (1.2-13.9) |
8.1 (1.1-60.3) |
1.4 (0.5-3.9) |
|
BMI (Kg/m2) |
|
|
|
|
|
|
|
|
|
|
| 18-22.9 |
26.7 |
35.3 |
26.8 |
25.3 |
1 |
|
|
1 |
|
|
| <18 |
3.8 |
11.8 |
3.6 |
10.1 |
2.3 (1.03-2.37) |
0.94 (0.19-4.56) |
2.8 (1.12-7.11) |
2.8 (1.2-6.6) |
3.1 (1.1-8.3) |
1.1 (0.2-5.0) |
| 23-24.9 |
22.9 |
21.0 |
26.8 |
27.3 |
0.69 (0.39-1.23) |
1.16 (0.53-2.52) |
1.25 (0.53-2.52) |
0.7 (0.3-1.3) |
1.3 (0.6-2.4) |
1.1 (0.5-2.4) |
| ≥ 25 |
46.6 |
31.9 |
42.9 |
37.4 |
0.51 (0.31-0.85) |
0.91 (0.45-1.82) |
0.84 (0.48-1.48) |
0.6 (0.3-1.1) |
0.9 (0.5-1.7) |
1.0 (0.5-2.0) |
|
Maximum diameter (cm) |
|
|
|
|
|
|
|
|
|
|
| <5 |
62.5 |
49.6 |
62.5 |
33.3 |
1 |
|
|
1 |
|
|
| 5-10 |
29.1 |
39.5 |
32.1 |
40.5 |
1.7 (1.09-2.6) |
1.1 (0.59-2.0) |
2.6 (1.5-4.3) |
1.5 (0.9-2.5) |
2.3 (1.3-4.0) |
0.9 (0.5-1.7) |
| >10 |
8.4 |
10.9 |
5.4 |
26.3 |
1.64 (0.8-3.3) |
0.64 (0.18-2.2) |
5.8 (3.1-11.1) |
1.0 (0.5-2.2) |
4.0 (2.0-7.9) |
0.5 (0.1-1.7) |
|
Duration between diagnosis of CLD and HCC | ||||||||||
| >55 |
22.1 |
6.7 |
19.6 |
10.1 |
1 |
|
|
1 |
|
|
| zero |
37.5 |
52.1 |
44.6 |
65.7 |
4.5 (2.0-10.0) |
1.3 (0.62-2.8) |
3.8 (1.8-7.8) |
3.7 (1.6-8.4) |
3.0 (1.4-6.5) |
1.1 (0.4-2.4) |
| 1-55 |
40.4 |
41.2 |
35.7 |
24.2 |
3.3 (1.5-7.4) |
0.9 (0.4-2.1) |
1.3 (0.5-2.8) |
2.6 (1.1-6.1) |
1.2 (0.5-2.8) |
0.7 (0.3-1.7) |
|
Diabetes |
|
|
|
|
|
|
|
|
|
|
| No |
55.8 |
72.3 |
78.6 |
49.5 |
1 |
|
|
1 |
|
|
| Yes | 44.2 | 27.7 | 21.4 | 50.5 | 0.48 (0.30-0.76) | 0.34 (0.17-0.67) | 1.2 (0.8-2.0) | 0.5 (0.3-0.9) | 1.6 (0.1-2.5) | 0.3 (0.2-0.6) |