Table 2.
Overall responsea (2661/3163) | Provided clinical information at home or clinicb (2231/2,630) | Completed clinic visitc (1690/2,229) | Mutually adjustedd overall response (n = 2,143) | Mutually adjustede visit cooperation (n = 1,986) | Mutually adjustedf CRF cooperation (n = 1,717) | |
---|---|---|---|---|---|---|
n (% responded) | n (% cooperated) | n (% cooperated) | OR (95 %CI) | OR (95 %CI) | OR (95 %CI) | |
Childhood | ||||||
Childhood cognitive score | p < 0.001 | p = 0.03 | p < 0.001 | p = 0.01 | p = 0.2 | p = 0.001 |
Top 10 % | 261 (90.0) | 225 (88.3) | 190 (84.4) | 1 | 1 | 1 |
Middle 80 % | 2,020 (85.6) | 1,707 (85.4) | 1,299 (76.1) | 0.63 (0.33, 1.21) | 1.22 (0.75, 1.99) | 0.69 (0.44, 1.08) |
Bottom 10 % | 182 (71.7) | 142 (79.3) | 79 (55.6) | 0.35 (0.16, 0.76) | 0.80 (0.41, 1.57) | 0.33 (0.18, 0.62) |
Adulthood | ||||||
Verbal memory at 53 years | p < 0.001 | p < 0.001 | p < 0.001 | p = 0.02 | p = 0.01 | p = 0.002 |
Top 10 % | 327 (97.0) | 299 (92.3) | 259 (86.6) | 1 | 1 | 1 |
Middle 80 % | 1,875 (88.4) | 1,631 (88.1) | 1,248 (76.5) | 0.36 (0.17, 0.76) | 0.67 (0.40, 1.12) | 0.59 (0.39, 0.89) |
Bottom 10 % | 208 (81.3) | 160 (77.3) | 89 (55.6) | 0.39 (0.16, 0.91) | 0.39 (0.21, 0.75) | 0.37 (0.21, 0.63) |
Physical performance score at 53 years | p < 0.001 | p = 0.005 | p < 0.001 | p > 0.9 | p = 0.4 | p = 0.2 |
Top 10 % | 236 (91.5) | 215 (91.9) | 177 (82.3) | 1 | 1 | 1 |
Middle 80 % | 1,866 (88.7) | 1,615 (87.6) | 1,238 (76.7) | 0.95 (0.56, 1.61) | 1.01 (0.60, 1.67) | 0.94 (0.62, 1.42) |
Bottom 10 % | 190 (79.8) | 152 (81.3) | 96 (63.2) | 0.90 (0.44, 1.86) | 0.74 (0.38, 1.42) | 0.63 (0.36, 1.12) |
Functional limitations at 53 years | p < 0.001 | p = 0.3 | p < 0.001 | p = 0.1 | p = 0.5 | |
No difficulties walking | 2,263 (89.0) | 1,953 (87.3) | 1,516 (77.6) | 1 | 1 | |
Severe difficulties walking | 140 (74.1) | 115 (83.9) | 65 (56.5) | 0.71 (0.40, 1.28) | 0.85 (0.50, 1.43) | |
Mental health profiles to 53 years | p = 0.4 | p = 0.4 | p = 0.9 | |||
Absence of symptoms | 1,275 (88.3) | 1,085 (86.2) | 826 (76.1) | |||
Repeat symptoms | 567 (89.0) | 499 (89.1) | 377 (75.6) | |||
Adolescent onset, adult well | 361 (88.5) | 313 (87.2) | 241 (77.0) | |||
Adult onset | 221 (85.0) | 192 (88.1) | 143 (74.5) | |||
GHQ score at 53 years | p = 0.1 | p = 0.3 | p = 0.7 | p = 0.9 | ||
4 or fewer symptoms | 1,960 (88.7) | 1,682 (86.9) | 1,275 (75.8) | 1 | ||
5 + symptoms | 442 (86.3) | 388 (88.6) | 298 (76.8) | 0.97 (0.67, 1.42) | ||
Health problems at 53 years | p < 0.001 | p = 0.5 | p = 0.01 | p = 0.11 | p = 0.6 | |
No health problems | 1,517 (89.8) | 1,308 (87.1) | 1,022 (78.1) | 1 | 0.87 (0.67, 1.13) | |
1 health problem | 713 (86.1) | 621 (88.1) | 457 (73.6) | 0.72 (0.52, 1.00) | ||
2 + health problems | 228 (81.4) | 189 (85.1) | 132 (69.8) | 0.68 (0.40, 1.16) | 0.90 (0.57, 1.43) | |
Cardiovascular at disease at 53 years | p = 0.001 | p = 0.8 | p = 0.08 | p = 0.3 | p = 0.6 | |
No | 2,337 (88.4) | 2,015 (87.2) | 1,540 (76.4) | 1 | 1 | |
Yes | 121 (79.6) | 103 (88.0) | 71 (68.9) | 0.73 (0.41, 1.32) | 1.18 (0.65, 2.12) | |
Obese at 53 years | p = 0.04 | p < 0.001 | p < 0.001 | p > 0.9 | p < 0.001 | p = 0.02 |
No | 1,866 (88.8) | 1,643 (88.9) | 1,284 (78.2) | 1 | 1 | 1 |
Yes (BMI ≥ 30kg/m2) | 570 (85.8) | 462 (82.4) | 321 (69.5) | 0.98 (0.70, 1.39) | 0.57 (0.42, 0.77) | 0.73 (0.55, g0.95) |
Lifetime smoking to 53 years | p < 0.001 | p < 0.001 | p < 0.001 | p < 0.001 | p = 0.006 | p < 0.001 |
Never smoker | 751 (88.2) | 644 (86.7) | 514 (79.8) | 1 | 1 | 1 |
Predominantly non-smoker | 869 (89.2) | 769 (89.4) | 608 (79.1) | 1.20 (0.80, 1.79) | 1.24 (0.86, 1.80) | 0.81 (0.60, 1.08) |
Predominantly smoker | 514 (84.8) | 424 (84.0) | 301 (71.0) | 0.73 (0.48, 1.11) | 0.80 (0.54, 1.18) | 0.70 (0.50, 0.98) |
Lifelong smoker | 345 (76.0) | 265 (77.5) | 169 (63.8) | 0.46 (0.30, 0.70) | 0.61 (0.40, 0.92) | 0.44 (0.31, 0.64) |
Physical activity at 53 years | p < 0.001 | p < 0.001 | p < 0.001 | p = 0.05 | p = 0.07 | p = 0.02 |
Very active | 860 (91.0) | 759 (89.3) | 613 (80.8) | 1 | 1 | 1 |
Moderately active | 462 (92.2) | 418 (91.3) | 339 (81.0) | 1.41 (0.87, 2.28) | 1.52 (0.97, 2.40) | 1.23 (0.87, 1.73) |
Inactive | 1,135 (84.1) | 941 (83.9) | 659 (70.0) | 0.82 (0.58, 1.15) | 0.91 (0.66, 1.26) | 0.80 (0.61, 1.04) |
CAGE alcohol problems at 53 years | p = 0.3 | p = 0.3 | p = 0.8 | |||
No/1 problem | 2,147 (88.7) | 1,855 (87.4) | 1,424 (76.8) | |||
2 + problems | 167 (86.1) | 148 (90.2) | 115 (77.7) |
aResponse rate is number providing any information divided by eligible sample
bCooperation rate is number providing any clinical information at clinic or home visit divided by number providing any information less 31 study members who died between initial and CRF invitation
cCooperation rate is number completing clinic visit divided by number providing any clinical information at clinic or home
dLogistic regression model includes cognitive score at 8 years and verbal memory, physical performance, functional limitations, GHQ score, health problems, cardiovascular disease, obesity, lifelong smoking, physical activity and sex all at 53 years
eLogistic regression model includes cognitive score at 8 years and verbal memory, physical performance, obesity, lifelong smoking, physical activity and sex all at 53 years
fLogistic regression model includes cognitive score at 8 years and verbal memory, physical performance, functional limitations, health problems, cardiovascular disease, obesity, lifelong smoking, physical activity and sex all at 53 years
Blank cells indicate where characteristic not included in multiply adjusted model