Table 1.

Neuropsychiatric Disorders are Due to Dysfunctional Glia Cells and Currently used Pharmacological Treatments Target Directly Glia Cells in Addition to Neurons

Neuropsychiatric Disorder	Glia Cells Affected (Direct/Indirect Evidences)	Pharmacotherapy	Glia Cells Responsiveness (Direct Effects)
Major Depressive Disorder	Astrocytes [14,36,104] Oligodendrocytes [5,39] Microglia cells [5,73]	Antidepressants Mood stabilizers	Astrocytes [36,38,59,100,132] Oligodendrocytes [11,62] Microglia cells [125]
Bipolar Disorder	Oligodendrocytes [27] Microglia cells [15]	Antipsychotics Mood stabilizers	Astrocytes [38,100,132] Oligodendrocytes [11,69]
Anxiety disorders	Astrocytes [10] Oligodendrocytes [10]	Antidepressants Antipsychotics Mood stabilizers Anticonvulsants/ Antiepileptics Benzodiazepines Drugs targeting glutamatergic system	Astrocytes [13,36,38,59,100,123,131,132] Oligodendrocytes [11,62,69] Microglia cells [31,125,128]
Schizophrenia	Astrocytes [74] Oligodendrocytes [16,24,45]	Antipsychotics	Astrocytes [38] Oligodendrocytes [69]
Attention Deficit Hyperactivity Disorder	Astrocyte [25,90,111] Oligodendrocytes [25]	Psychostimulants	Astrocytes [117] Microglia cells [129]
Autism Spectrum Disorder	Oligodendrocytes [115]	Antidepressants Antipsychotics Anticonvulsants/ Antiepileptics Psychostimulants	Astrocytes [36,38,59,100,117,123,131] Oligodendrocytes [62,69] Microglia cells [125,129]
Epilepsy	Astrocytes [123] Microglia cells [33]	Anticonvulsants/ Antiepileptics	Astrocytes [123,131]