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. 2013 Apr 23;10:36. doi: 10.1186/1743-7075-10-36

Table 2.

Baseline, 8 weeks, and change from baseline to 8 weeks concentrations for n3 and n6 plasma phospholipid fatty acids in μg/ml1

  High fat
 Low fat
 Low fat + n-3
  
n = 17 n = 16 n = 17 p-value2
18:2n6
  
  
  
  
   Baseline
 280.69 ± 14.57
 284.66 ± 14.76
 293.95 ± 14.59
 0.41
   8 weeks
 285.49 ± 12.54a
 269.21 ± 12.86a
 233.08 ± 12.59b*
 0.0006
   Δ 8 weeks
 4.81 ± 10.90a
 −16.08 ± 11.29a
 −60.85 ± 10.95b
 0.0001
   p-value3
 0.66
 0.16
 < 0.0001
  
18:3n3
  
  
  
  
   Baseline
 4.00 ± 0.86
 4.51 ± 0.88
 3.22 ± 0.86
 0.34
   8 weeks
 2.57 ± 0.45a
 3.12 ± 0.47a
 6.85 ± 0.45b*
 < 0.0001
   Δ 8 weeks
 −1.43 ± 0.79a
 −1.30 ± 0.82a
 3.62 ± 0.79b
 < 0.0001
   p-value3
 0.08
 0.12
 < 0.0001
  
20:4n6
  
  
  
  
   Baseline
 120.62 ± 7.83
 121.51 ± 7.94
 126.04 ± 7.84
 0.59
   8 weeks
 107.89 ± 7.14a*
 135.62 ± 7.34b*
 100.12 ± 7.17a*
 0.0001
   Δ 8 weeks
 −12.72 ± 5.13a
 13.47 ± 5.33b
 −25.90 ± 5.16a
 < 0.0001
   p-value3
 0.02
 0.02
 < 0.0001
  
20:5n-3
  
  
  
  
   Baseline
 11.43 ± 1.77
 11.80 ± 1.82
 9.69 ± 1.78
 0.49
   8 weeks
 6.89 ± 1.80a*
 9.99 ± 1.87a
 29.86 ± 1.81b*
 < 0.0001
   Δ 8 weeks
 −4.54 ± 1.94a
 −1.91 ± 2.02a
 20.17 ± 1.96b
 < 0.0001
   p-value3
 0.02
 0.35
 < 0.0001
  
22:5n-3
  
  
  
  
   Baseline
 9.94 ± 0.78
 10.56 ± 0.79
 10.72 ± 0.78
 0.49
   8 weeks
 8.41 ± 0.88a*
 11.04 ± 0.91b
 13.45 ± 0.89c*
 < 0.0001
   Δ 8 weeks
 −1.52 ± 0.69a
 0.36 ± 0.72a
 2.73 ± 0.70b
 < 0.0001
   p-value3
 0.03
 0.62
 0.0003
  
22:6n-3
  
  
  
  
   Baseline
 30.18 ± 2.82
 28.90 ± 2.89
 29.68 ± 2.83
 0.89
   8 weeks
 24.06 ± 3.77a*
 35.03 ± 3.90b*
 55.00 ± 3.78c*
 < 0.0001
   Δ 8 weeks
 −6.12 ± 2.56a
 5.95 ± 2.65b
 25.32 ± 2.57c
 < 0.0001
   p-value3
 0.02
 0.03
 < 0.0001
  
Total n-3
  
  
  
  
   Baseline
 59.71 ± 5.33
 60.07 ± 5.42
 56.75 ± 5.34
 0.68
   8 weeks
 44.50 ± 6.37a*
 62.86 ± 6.60b
 110.10 ± 6.41c*
 < 0.0001
   Δ 8 weeks
 −15.21 ± 4.95a
 2.55 ± 5.14b
 54.36 ± 4.98c
 < 0.0001
   p-value3
 0.004
 0.62
 < 0.0001
  
Total n-6
  
  
  
  
   Baseline
 452.87 ± 21.30
 456.78 ± 21.57
 468.55 ± 21.34
 0.53
   8 weeks
 432.99 ± 18.17a
 458.41 ± 18.74a
 370.63 ± 18.25b*
 0.0005
   Δ 8 weeks
 −19.85 ± 14.82a
 −0.58 ±15.34a
 −97.85 ± 14.89b
 < 0.0001
   p-value3 0.19 0.97 < 0.0001  

1All values are LS means ± standard error.

2p-value for effect of treatment across the three diets evaluated using a general linear mixed model. Values with differing letters as a superscript are significantly different at p < 0.05.

3p-value for paired t-test comparing baseline and 8 weeks means within each diet.

*8 week mean is significantly different from baseline mean.