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. 2013 Apr 23;10:36. doi: 10.1186/1743-7075-10-36

Table 3.

Baseline and 8 week values for urinary estrogens and metabolites for the HF, LF and LFn3a

Analyte HF
 LF
 LFn3
 P-valued
n = 15b n = 15c n = 16
Estrone (E1) (nmol/day)
  
  
  
  
   Baseline
 6.7 (4.8, 9.5)
 7.2 (5.1, 10.1)
 8.1 (5.8, 11.5)
 0.36
   8 weeks
 6.3 (4.4, 9.1) §
 9.9 (6.9, 14.2) †**
 8.5 (5.9, 12.1) †
 0.004
   P-valuee
 0.39
 0.02
 0.92
  
Estradiol (E2) (nmol/day)
  
  
  
  
   Baseline
 2.0 (1.0, 3.8)
 2.2 (1.2, 4.3)
 1.4 (0.7, 2.6)
 0.36
   8 weeks
 1.0 (0.5, 2.1)
 2.1 (1.0, 4.4)
 1.7 (0.8, 3.4)
 0.12
   P-valuee
 0.37
 0.47
 0.83
  
Estriol (E3) (nmol/day)
  
  
  
  
   Baseline
 7.2 (3.1, 16.8)
 8.5 (3.6, 19.9)
 10.8 (4.7, 25.0)
 0.62
   8 weeks
 11.8 (6.3, 22.0)
 14.3 (7.7, 26.7)
 11.7 (6.3, 21.5)
 0.79
   P-valuee
 0.84
 0.12
 0.64
  
E1 + E2 + E3 (nmol/day)
  
  
  
  
   Baseline
 22.9 (15.3, 34.4)
 24.8 (16.6, 37.1)
 23.0 (15.4, 34.2)
 0.77
   8 weeks
 21.5 (14.3, 32.2)§
 35.7 (23.9, 53.4)†**
 26.8 (18.1, 39.8)§†
 0.03
   P-valuee
 0.51
 0.02
 0.60
  
2-hydroxyestrone (2OH-E1) (nmol/day)
  
  
  
   Baseline
 22.7 (16.5, 31.2)§†
 25.0 (18.2, 34.4)§
 18.5 (13.5, 25.3)†
 0.02
   8 weeksf
 17.6 (13.7, 22.7)
 20.4 (15.8, 26.3)
 24.1 (18.8, 30.9)
 0.23
   P-valuee
 0.19
 0.81
 0.29
  
2-methoxyestrone (2-ME1)(nmol/day)
  
  
  
   Baseline
 1.6 (0.7, 3.8)
 3.4 (1.5, 7.8)
 3.1 (1.4, 7.1)
 0.21
   8 weeks
 1.4 (0.7, 3.1)
 2.1 (0.9, 4.5)
 3.3 (1.5, 7.1)
 0.23
   P-valuee
 0.98
 0.48
 0.91
  
2-methoxyestradiol (2-ME2) (nmol/day)
  
  
  
   Baseline
 1.3 (0.6, 3.3)
 3.9 (1.6, 9.4)
 1.7 (0.7, 3.9)
 0.09
   8 weeks
 0.9 (0.4, 2.1)
 1.0 (0.4, 2.3)
 1.7 (0.8, 4.0)
 0.39
   P-valuee
 0.84
 0.08
 0.57
  
4-hydroxyestrone (4OH-E1) (nmol/day)
  
  
  
   Baseline
 0.78 (0.51, 1.21)
 1.08 (0.70, 1.68)
 1.17 (0.76, 1.80)
 0.21
   8 weeks
 0.92 (0.66, 1.27)
 1.05 (0.76, 1.45)
 1.28 (0.93, 1.75)
 0.25
   P-valuee
 0.64
 0.93
 0.50
  
16α-hydroxyestrone (16αOH-E1) (nmol/day)
  
  
  
   Baseline
 2.03 (1.10, 3.75)
 2.39 (1.29, 4.44)
 1.70 (0.93, 3.11)
 0.62
   8 weeks
 1.50 (0.82, 2.74)
 2.34 (1.27, 4.29)
 2.03 (1.12, 3.65)
 0.52
   P-valuee
 0.47
 0.22
 0.32
  
Total Estrogens (nmol/day)
  
  
  
  
   Baseline
 73.7 (52.7, 100.1)
 83.7 (60.9, 115.0)
 72.8 (53.1, 99.6)
 0.38
   8 weeks
 65.5 (45.8, 93.8)
 86.4 (60.7, 123.0)
 80.6 (57.0, 113.9)
 0.27
   P-valuee
 0.78
 0.54
 0.40
  
2:16αOH-E1 ratio (nmol/day)
  
  
  
  
   Baseline
 11.3 (5.4, 23.6)
 10.5 (5.0, 21.9)
 10.8 (5.3, 22.4)
 0.98
   8 weeks
 11.9 (5.7, 25.2)
 10.0 (4.7, 21.3)
 10.4 (5.0, 21.7)
 0.90
   P-valuee 0.90 0.12 0.72  

HF: high fat diet; LF: low fat diet; LFn3: low fat + omega-3 fatty acids diet; E1: estrone;

2:16αOH-E1 ratio: 2-hydroxy estrone:16α-hydroxy estrone ratio.

aAll values are geometric means (95% confidence interval).

bOne subject was missing urines for HF diet, thus n = 15 for HF.

cOne subject was missing urines for LF diet, thus n = 15 for LF.

dP-value for effect of treatment across the three diets; values with differing symbols (§,†) as a superscript are significantly different.

eP-value for paired t-test comparing baseline and 8 weeks means within each diet.

**8 weeks mean is significantly different from baseline mean.

f8 weeks means were adjusted for baseline 2OH-E1.