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. 2013 Apr 3;11:86. doi: 10.1186/1479-5876-11-86

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Copyright © 2013 Shi et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Toxicity observation. (a) Body weights of mice were plotted and the curve of the Ad-PEDF/Lipo-treated and Ad-null/Lipo-treated group paralleled very closely to that of the Ad-PEDF group and ns group with no significant differences among them (P > 0.05). (b) The Hematoxylin and eosin (H&E) staining of heart, liver, spleen and kidney. After mice were sacrificed histological sections were taken from lungs of mice, and analyzed at × 200 magnification. The organs kept primitively normal without inflammatory cells infiltration and necrosis in each group.