Skip to main content
. Author manuscript; available in PMC: 2013 Nov 1.
Published in final edited form as: Nat Neurosci. 2013 Mar 31;16(5):571–579. doi: 10.1038/nn.3357

Figure 8.

Figure 8

Excision of mutant SOD1 (G37R) from NG2+ cells delays disease onset and prolongs survival in ALS mice. (a) Plots of disease onset (median, −4HT: 235 d (n = 15); +4HT: 304 d (n = 20), P = 0.0003, Log-Rank test), early disease (median, −4HT: 330 d (n = 13); +4HT: 413 d (n = 14), P = 0.001), and survival (median, −4HT: 419 d (n = 12); +4HT: 554 d (n = 14), P = 0.0005) of PDGFαR-CreER;loxSOD1 (G37R) mice. (b) Comparison of mean age at disease onset (−4HT: 244 ± 10 d; +4HT: 307 ± 11 d, P = 0.0005), early disease (−4HT: 336 ± 16 d; +4HT: 415 ± 13 d, P = 0.001) and survival (−4HT: 433 ± 18 d; +4HT: 518 ± 16 d, P = 0.0025,). Mean + s.e.m. ** P < 0.01; *** P < 0.005, Mann Whitney test. (c) Western blots of MCT1 expression from several −4HT and +4HT mice examined at disease onset. Full-length blots are presented in Supplementary Fig. 11.