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. Author manuscript; available in PMC: 2013 Nov 1.
Published in final edited form as: Nat Neurosci. 2013 Mar 24;16(5):613–621. doi: 10.1038/nn.3356

Figure 2. Modulation of DSBs by exploration of a novel environment, overexpression of hAPP/Aβ and reduction of endogenous tau.

Figure 2

(a) Schematic outline of the experimental design (see Methods for details). For all experiments, investigators were blinded with respect to the genotype and treatment of mice. (b–e) For each brain region, the number of γH2A.X-positive foci in 4–6-month-old mice of the indicated genotypes was counted. n=4–9 mice per genotype and treatment from 2 independent experiments. *p<0.05; ***p<0.001 vs. mice of the same genotype exposed to the home cage condition, or as indicated by bracket. ##p<0.01; ###p<0.001 vs. WT (Tau+/+) mice exposed to the home cage condition (Bonferroni post-hoc test). Bars represent means ± SEM.