Figure 1. Loss of TH in SNpc of paraquat-treated PACAP KO mice.
Stereological counting of THpositive (TH+) and Total neurons (TH+Nissl+) in the substantia nigra pars compacta (SNpc) after administration of saline (white bars) or paraquat [10 mg/kg] (black bars) in WT and PACAP KO mice. (A) Representative images of SNpc in saline and paraquat treated WT and PACAP KO mice (blue:Nissl, brown:TH). Stereological estimates of TH+ (B) and Nissl+ (C) in the whole SNpc. *p<0.05 compared with corresponding saline group; using two-way ANOVA followed by Fisher’s LSD test, n=5–6 mice per group. Scale bar 250 µm.