Table 3.

Proteins implicated in misfolding aggregation diseases and respective targets for aggregation inhibitor compound design, as discussed herein.

Disease	Aggregating Protein	Direct Targets	Indirect Targets
Alzheimer’s	Amyloid-β	BACE-1 α-secretase γ-secretase Metal chelators	HMG-CoA reductase inhibitors Protein kinases (GSK3, CDK5) Autophagy activators
	Tau	Physiological tau
Parkinson’s	α-synuclein		HMG-CoA reductase inhibitors Protein kinases (LRRK2) Autophagy activators Heat Shock Protein
Huntington’s	Huntingtin	PolyQ aggregates	HMG-CoA reductase inhibitors Autophagy activators Heat Shock Protein
Amyotrophic lateral sclerosis	SOD1 and many others implicated		Protein Kinases (GSK3) Autophagy activators Heat Shock Protein