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. Author manuscript; available in PMC: 2014 Jan 1.
Published in final edited form as: Breast Cancer Res Treat. 2012 Nov 18;137(1):93–107. doi: 10.1007/s10549-012-2332-x

Fig. 2. LBH589 induced apoptosis and cell cycle arrest in AI-resistance cells.

Fig. 2

(A) LBH589 suppresses the expression of these apoptosis and cell cycle related molecules in a dose-dependent manner. Western blot analyses were performed on MCF-7aro and Exe-R cells that were treated with DMSO (control) or the indicated concentrations of LBH589 for 48 hours. (B) LBH589 induces cell cycle arrest. Flow cytometric analysis of DNA content of MCF-7aro and Exe-R cells treated with LBH589 (20 nM) or DMSO for 48 hours. Both non-adherent and adherent particles and cells were stained with propidium iodide.